Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells: Evidence of an Oxidant-Sensitive Pathway
Figure 2
Effects of captopril (CPT,
(a) and (b)), zofenoprilat (ZOF,
(a) and (c)), lisinopril (LIS,
(a) and (d)), enalaprilat (ENA,
(a) and (e)), and bradykinin (BK,
(a) and (f)) on nitric oxide production, as evaluated by nitrite plus nitrate
concentrations in culture medium (expressed as % of control) by vascular
endothelial cells derived from umbilical cord vein after 8 hours of incubation
both alone and in the presence of either ,
that is, a bradykinin receptor antagonist (B1ra, ), or ,
that is, a bradykinin receptor antagonist (B2ra, ), or the NO synthase competitive inhibitor -nitro-L-arginine methyl ester (L-NA,
). (A) versus control; (B)
or less versus CPT, LIS, ENA, and BK and versus control; (C)
or less versus control, CPT+B2ra and CPT+L-NA; (D) versus
control and ZOF+L-NA and versus ZOF+B2ra; (E)
versus control and ZOF+L-NA; (F) or less versus control,
LIS+B2ra and LIS+L-NA; (G) or less versus control, ENA+B2ra
and ENA+L-NA; (H) versus control, BK+B2ra and BK+L-NA.
