Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells: Evidence of an Oxidant-Sensitive Pathway

Figure 3

Effects of 10⁻⁸M captopril (CPT), zofenoprilat (ZOF), lisinopril (LIS), and enalaprilat on TNFα-induced intracellular oxidative stress as evaluated by dichlorofluorescein (DCF, (a)) and glutathione (GSH, (b)) content. (A) 𝑃<.01 or less versus control and TNF+ZOF and 𝑃<.002 versus TNF+CPT; (B) 𝑃<.0001 versus control and 𝑃<.01 versus TNF+ZOF. (C) 𝑃<.0001 versus TNF, TNF+CPT, TNF+LIS, and TNF+ENA and 𝑃<.02 versus TNF+ZOF; (D) 𝑃<.0004 or less versus TNF, TNF+CPT, TNF+LIS, and TNF+ENA.

(a)

(b)