Mediators of Inflammation
Volume 2008 (2008), Article ID 309721, 6 pages
doi:10.1155/2008/309721
Research Article
Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors
1Laboratory of Molecular Immunology, Institute of Clinical Immunology, Siberian Branch of Russian Academy of Medical Sciences (SB RAMS), Novosibirsk 630099, Russia
2Pharmacogenomic Group, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
Received 24 June 2008; Accepted 5 September 2008
Academic Editor: Magdalena Klink
Copyright © 2008 O. P. Khripko et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- K. Nakanishi, T. Yoshimoto, H. Tsutsui, and H. Okamura, “Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu,” Cytokine & Growth Factor Reviews, vol. 12, no. 1, pp. 53–72, 2001. View at Publisher · View at Google Scholar
- C. A. Dinarello, “Interleukin-18,” Methods, vol. 19, no. 1, pp. 121–132, 1999. View at Publisher · View at Google Scholar · View at PubMed
- H. Rothe, N. A. Jenkins, N. G. Copeland, and H. Kolb, “Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2,” The Journal of Clinical Investigation, vol. 99, no. 3, pp. 469–474, 1997. View at Publisher · View at Google Scholar · View at PubMed
- J. A. Gracie, R. J. Forsey, W. L. Chan, et al., “A proinflammatory role for IL-18 in rheumatoid arthritis,” The Journal of Clinical Investigation, vol. 104, no. 10, pp. 1393–1401, 1999. View at Publisher · View at Google Scholar · View at PubMed
- G. Monteleone, F. Trapasso, T. Parrello, et al., “Bioactive IL-18 expression is up-regulated in Crohn's disease,” The Journal of Immunology, vol. 163, no. 1, pp. 143–147, 1999.
- T. Yamano, T. Higashi, K. Nouso, et al., “Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis,” Clinical & Experimental Immunology, vol. 122, no. 2, pp. 227–231, 2000. View at Publisher · View at Google Scholar
- V. Giedraitis, B. He, W.-X. Huang, and J. Hillert, “Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation,” Journal of Neuroimmunology, vol. 112, no. 1-2, pp. 146–152, 2001. View at Publisher · View at Google Scholar
- A. W. Bushley, R. Ferrell, K. McDuffie, et al., “Polymorphisms of interleukin (IL)-1, IL-1, IL-6, IL-10, and IL-18 and the risk of ovarian cancer,” Gynecologic Oncology, vol. 95, no. 3, pp. 672–679, 2004. View at Publisher · View at Google Scholar · View at PubMed
- C. Pratesi, M. T. Bortolin, E. Bidoli, et al., “Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type,” Cancer Immunology, Immunotherapy, vol. 55, no. 1, pp. 23–30, 2006. View at Publisher · View at Google Scholar · View at PubMed
- M. Imboden, A. Nieters, A. J. Bircher, et al., “Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA),” Clinical and Molecular Allergy, vol. 4, no. 1, article 9, pp. 1–9, 2006. View at Publisher · View at Google Scholar · View at PubMed
- P.-A. Zhang, J.-M. Wu, Y. Li, and X.-S. Yang, “Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population,” World Journal of Gastroenterology, vol. 11, no. 11, pp. 1594–1598, 2005.
- F. Mosteller and J. Tukey, Data Analysis and Regression: A Second Course in Statistics, Addison Wesley, Reading, Mass, USA, 1977.
- E. V. Gubler, Calculation Methods of Analysis and Recognition of Pathological Processes, Medizine, Leningrad, Russia, 1978.
- Y.-S. Wei, Y. Lan, Y.-G. Liu, H. Tang, R.-G. Tang, and J.-C. Wang, “Interleukin-18 gene promoter polymorphisms and the risk of esophageal squamous cell carcinoma,” Acta Oncologica, vol. 46, no. 8, pp. 1090–1096, 2007. View at Publisher · View at Google Scholar · View at PubMed
- T. Takada, E. Suzuki, T. Ishida, et al., “Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population,” Tissue Antigens, vol. 58, no. 5, pp. 293–298, 2001. View at Publisher · View at Google Scholar
- J. Arimitsu, T. Hirano, S. Higa, et al., “IL-18 gene polymorphisms affect IL-18 production capability by monocytes,” Biochemical and Biophysical Research Communications, vol. 342, no. 4, pp. 1413–1416, 2006. View at Publisher · View at Google Scholar · View at PubMed
- H. Tanaka, N. Miyazaki, K. Oashi, et al., “IL-18 might reflect disease activity in mild and moderate asthma exacerbation,” Journal of Allergy and Clinical Immunology, vol. 107, no. 2, pp. 331–336, 2001. View at Publisher · View at Google Scholar · View at PubMed
- S. Higa, T. Hirano, M. Mayumi, et al., “Association between interleukin-18 gene polymorphism 105A/C and asthma,” Clinical & Experimental Allergy, vol. 33, no. 8, pp. 1097–1102, 2003. View at Publisher · View at Google Scholar
- E. Héninger, A. Treszl, I. Kocsis, B. Dérfalvi, T. Tulassay, and B. Vásárhelyi, “Genetic variants of the interleukin-18 promoter region (-607) influence the course of necrotising enterocolitis in very low birth weight neonates,” European Journal of Pediatrics, vol. 161, no. 7, pp. 410–411, 2002. View at Publisher · View at Google Scholar