Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine
Figure 2
NF-κB activity in the brain area surrounding the injury site in SHAM
group (n = 5), TBI group (n = 6), and TBI-NAC group (n = 6). (Upper) EMSA
autoradiography of NF-κB DNA binding activity. (Bottom) levels of NF-κB DNA binding activity quantified by computer-assisted densitometric
scanning and expressed as arbitrary densitometric units (ADUs). As compared with SHAM group, NF-κB binding activity measured by EMSA was significantly increased
in TBI group. Compared to TBI group, NAC significantly suppressed NF-κB activation in TBI-NAC
group. versus SHAM group, versus
TBI group.