Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine
Figure 3
Changes of inflammatory mediators in the injured brains as determined by ELISA in SHAM group
(n = 5), TBI group (n = 6), and TBI-NAC group
(n = 6). TBI could induce the significantly increased concentrations of IL-1β,
TNF-α, and IL-6 in the rat brain surrounding the injury site. In TBI-NAC group, the cortical
concentrations of IL-1β and TNF-α but not IL-6 were markedly downregulated as
compared with that of TBI group. versus SHAM group;
and versus TBI group.
