Mediators of Inflammation
Volume 2008 (2008), Article ID 892864, 8 pages
doi:10.1155/2008/892864
Research Article

Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women

Panayoula C. Tsiotra,1 Constantine Tsigos,1 Eleni Anastasiou,2 Eleni Yfanti,1 Eleni Boutati,3 Emmanouil Souvatzoglou,2 Ioannis Kyrou,1 and Sotirios A. Raptis1

1Division of Basic Sciences, Hellenic National Center for the Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 10675 Athens, Greece
2Department of Internal Medicine, First Endocrine Section and Diabetes Centre, “Alexandra” Hospital, 11528 Athens, Greece
3Second Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, “Attikon” University General Hospital, Haidari, 11527 Athens, Greece

Received 22 July 2008; Accepted 9 October 2008

Academic Editor: V. L. Petricevich

Copyright © 2008 Panayoula C. Tsiotra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Steppan, S. T. Bailey, S. Bhat, et al., “The hormone resistin links obesity to diabetes,” Nature, vol. 409, no. 6818, pp. 307–312, 2001.
  2. H. Tilg and A. R. Moschen, “Adipocytokines: mediators linking adipose tissue, inflammation and immunity,” Nature Reviews Immunology, vol. 6, no. 10, pp. 772–783, 2006.
  3. J. N. Fain, “Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells,” Vitamins & Hormones, vol. 74, pp. 443–477, 2006.
  4. A. Bouloumié, C. A. Curat, C. Sengenès, K. Lolmède, A. Miranville, and R. Busse, “Role of macrophage tissue infiltration in metabolic diseases,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 8, no. 4, pp. 347–354, 2005.
  5. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005.
  6. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante Jr., “Obesity is associated with macrophage accumulation in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796–1808, 2003.
  7. C. A. Curat, V. Wegner, C. Sengenès, et al., “Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin,” Diabetologia, vol. 49, no. 4, pp. 744–747, 2006.
  8. I. N. Holcomb, R. C. Kabakoff, B. Chan, et al., “FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family,” The EMBO Journal, vol. 19, no. 15, pp. 4046–4055, 2000.
  9. M. Lehrke, M. P. Reilly, S. C. Millington, N. Iqbal, D. J. Rader, and M. A. Lazar, “An inflammatory cascade leading to hyperresistinemia in humans,” PLoS Medicine, vol. 1, pp. 161–168, 2004.
  10. P. D. Anderson, N. N. Mehta, M. L. Wolfe, et al., “Innate immunity modulates adipokines in humans,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 6, pp. 2272–2279, 2007.
  11. M. Bokarewa, I. Nagaev, L. Dahlberg, U. Smith, and A. Tarkowski, “Resistin, an adipokine with potent proinflammatory properties,” The Journal of Immunology, vol. 174, no. 9, pp. 5789–5795, 2005.
  12. M. Bajaj, S. Suraamornkul, L. J. Hardies, T. Pratipanawatr, and R. A. DeFronzo, “Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients,” International Journal of Obesity, vol. 28, no. 6, pp. 783–789, 2004.
  13. M. von Eynatten, J. G. Schneider, S. Hadziselimovic, et al., “Adipocytokines as a novel target for the anti-inflammatory effect of atorvastatin in patients with type 2 diabetes,” Diabetes Care, vol. 28, no. 3, pp. 754–755, 2005.
  14. N. Silswal, A. K. Singh, B. Aruna, S. Mukhopadhyay, S. Ghosh, and N. Z. Ehtesham, “Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway,” Biochemical and Biophysical Research Communications, vol. 334, no. 4, pp. 1092–1101, 2005.
  15. C. Rae and A. Graham, “Human resistin promotes macrophage lipid accumulation,” Diabetologia, vol. 49, no. 5, pp. 1112–1114, 2006.
  16. D. Kawanami, K. Maemura, N. Takeda, et al., “Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions,” Biochemical and Biophysical Research Communications, vol. 314, no. 2, pp. 415–419, 2004.
  17. H. S. Jung, K.-H. Park, Y. M. Cho, et al., “Resistin is secreted from macrophages in atheromas and promotes atherosclerosis,” Cardiovascular Research, vol. 69, no. 1, pp. 76–85, 2006.
  18. M. P. Reilly, M. Lehrke, M. L. Wolfe, A. Rohatgi, M. A. Lazar, and D. J. Rader, “Resistin is an inflammatory marker of atherosclerosis in humans,” Circulation, vol. 111, no. 7, pp. 932–939, 2005.
  19. M. S. Burnett, J. M. Devaney, R. J. Adenika, R. Lindsay, and B. V. Howard, “Cross-sectional associations of resistin, coronary heart disease, and insulin resistance,” The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 1, pp. 64–68, 2006.
  20. V. Beauloye, F. Zech, H. T. T. Mong, P. Clapuyt, M. Maes, and S. M. Brichard, “Determinants of early atherosclerosis in obese children and adolescents,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 8, pp. 3025–3032, 2007.
  21. L. Patel, A. C. Buckels, I. J. Kinghorn, et al., “Resistin is expressed in human macrophages and directly regulated by PPARγ activators,” Biochemical and Biophysical Research Communications, vol. 300, no. 2, pp. 472–476, 2003.
  22. M. W. Rajala, S. Obici, P. E. Scherer, and L. Rossetti, “Adipose-derived resistin and gut-derived resistin-like molecule-β selectively impair insulin action on glucose production,” Journal of Clinical Investigation, vol. 111, no. 2, pp. 225–230, 2003.
  23. R. R. Banerjee, S. M. Rangwala, J. S. Shapiro, et al., “Regulation of fasted blood glucose by resistin,” Science, vol. 303, no. 5661, pp. 1195–1198, 2004.
  24. J. Janke, S. Engeli, K. Gorzelniak, F. C. Luft, and A. M. Sharma, “Resistin gene expression in human adipocytes is not related to insulin resistance,” Obesity Research, vol. 10, no. 1, pp. 1–5, 2002.
  25. J. H. Lee, J. L. Chan, N. Yiannakouris, et al., “Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 10, pp. 4848–4856, 2003.
  26. K. M. Utzschneider, D. B. Carr, J. Tong, et al., “Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans,” Diabetologia, vol. 48, no. 11, pp. 2330–2333, 2005.
  27. M. Degawa-Yamauchi, J. E. Bovenkerk, B. E. Juliar, et al., “Serum resistin (FIZZ3) protein is increased in obese humans,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 11, pp. 5452–5455, 2003.
  28. B.-S. Youn, K.-Y. Yu, H. J. Park, et al., “Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus,” The Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 1, pp. 150–156, 2004.
  29. Y. Tokuyama, H. Osawa, T. Ishizuka, et al., “Serum resistin level is associated with insulin sensitivity in Japanese patients with type 2 diabetes mellitus,” Metabolism, vol. 56, no. 5, pp. 693–698, 2007.
  30. P. C. Tsiotra, C. Tsigos, E. Yfanti, et al., “Visfatin, TNF-α and IL-6 mRNA expression is increased in mononuclear cells from type 2 diabetic women,” Hormone and Metabolic Research, vol. 39, no. 10, pp. 758–763, 2007.
  31. P. C. Tsiotra, C. Tsigos, C. Gatsiou, and S. A. Raptis, “Effects of glucose, insulin and leptin on resistin mRNA and protein production from human peripheral monocytes,” International Journal Obesity, vol. 28, supplement 1, p. S130, 2004.
  32. J. Kawashima, K. Tsuruzoe, H. Motoshima, et al., “Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes,” Diabetologia, vol. 46, no. 2, pp. 231–240, 2003.
  33. E. Krušinová, M. Klementová, J. Kopecký, et al., “Effect of acute hyperinsulinaemia with and without angiotensin II type 1 receptor blockade on resistin and adiponectin concentrations and expressions in healthy subjects,” European Journal of Endocrinology, vol. 157, no. 4, pp. 443–449, 2007.
  34. E. Maury, K. Ehala-Aleksejev, Y. Guiot, R. Detry, A. Vandenhooft, and S. M. Brichard, “Adipokines oversecreted by omental adipose tissue in human obesity,” American Journal of Physiology, vol. 293, no. 3, pp. E656–E665, 2007.
  35. P. Arner, “Resistin: yet another adipokine tells us that men are not mice,” Diabetologia, vol. 48, no. 11, pp. 2203–2205, 2005.
  36. H.-L. Lu, H.-W. Wang, Y. Wen, M.-X. Zhang, and H.-H. Lin, “Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes,” World Journal of Gastroenterology, vol. 12, no. 11, pp. 1747–1751, 2006.
  37. J. Spranger, A. Kroke, M. Möhlig, et al., “Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study,” Diabetes, vol. 52, no. 3, pp. 812–817, 2003.
  38. E. Ruotsalainen, U. Salmenniemi, I. Vauhkonen, et al., “Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects,” Diabetes Care, vol. 29, no. 12, pp. 2714–2720, 2006.
  39. A. L. Carey, C. R. Bruce, M. Sacchetti, et al., “Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness,” Diabetologia, vol. 47, no. 6, pp. 1029–1037, 2004.
  40. P. Dandona, A. Aljada, and A. Bandyopadhyay, “Inflammation: the link between insulin resistance, obesity and diabetes,” Trends in Immunology, vol. 25, no. 1, pp. 4–7, 2004.
  41. R. Cancello and K. Clément, “Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue,” BJOG, vol. 113, no. 10, pp. 1141–1147, 2006.