Mediators of Inflammation in Acute Kidney Injury

Table 1

Inflammatory mediators of AKI.

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Caspases

Caspase-1

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Alpha-MSH

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Cytokines

(IFN-γ)

(TGF-𝛽)

(TNF-𝛼)

(IL-6)

(IL-10)

(IL-18)

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Chemokines

(CXCL1 (also known as KC or IL-8 in mice))

(CX3CL1 (also known as fractalkine))

(CCR1 (Chemokine receptor-1) ligands MIP-1alpha and RANTES)

(MCP-1)

(MIP-2)

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Adhesion molecules

(ICAM-1)

(P-selectin, E-selectin)

(CD147)

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Complement

 Alternative pathway

 C3A

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TLRs

 TLR-2

 TLR-4

 TLR-9

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Neutrophils

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Lymphocytes

 CD4

 CD8

 B cells

 Tregs

 NK cells

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Macrophages

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Dendritic cells

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