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Figure 4: (a), (c), Effect of Pinellia ternata, Citrus reticulata and their combinational prescription on Th2 cytokines (IL-4, IL-5, IL-13), Th1 cytokine (IFN-$\gamma$), eotaxin in BALF and IgE, histamine level in serum. (b), Effect of Pinellia ternata, Citrus reticulata and their combinational prescription on IL-5, IL-13 mRNA gene expression in lung tissue of OVA-induced murine model of asthma (seen materials and methods). (d), Immunomodulatory effects of Pinellia ternata, Citrus reticulata and their combinational prescription on OVA-specific Th1/Th2 cytokines production in spleen cells (described in materials and methods). The results are expressed the mean ± S.E ($N=5$). Statistically significant value compared with control group data by ANOVA or unpaired Student’s t-test (*$P<.05\text{,}$***$P<.001$). N: Normal Balb/c mice, CT: Ovalbumin inhalation (control group), CsA: OVA + CsA (10 mg/kg), OVA + PT(200, 400 mg/kg), OVA + CR(200, 400 mg/kg), OVA + (PT + CR) (200, 400 mg/kg).