Table 4: Effects of sulfasalazine, doxantrazole, quercetine, and nedocromil treatment on damage score, changes in colonic weight, body weight, and incidence of diarrhea and adhesions in reactivated TNBS colitis.
Group ()day 26th
Damage score(a) (0–10)
Colonic weight(b) (mg/cm)
Body weight change (%)
Adhesion (%)
Diarrhoea (%)
Noncolitic
0*
107.65 ± 6.80**
50.05 ± 2.45*
0*
0*
TNBS-control
5(3–6)
145.56 ± 3.03
40.58 ± 1.15
58
28.5
Sulfasalazine
1(1–4)
142.52 ± 5.77
45.02 ± 2.93
20
14.0
Doxantrazole
3(1–3)
132.50 ± 4.22
40.45 ± 2.58
58
28.5
Quercetin
2(1–3)
138.08 ± 3.00
44.49 ± 2.09
40
14.0
Nedocromil
1(1–3)
134.23 ± 5.82
46.78 ± 1.98
40
14.0
(a)Score data are expressed as median and interquartil interval.
(b)Colonic weight data are expressed as mean S.E.M.
*Groups differ significantly from the TNBS group . All groups differ significantly from the noncolitic (saline) group (, not shown).