Mediators of Inflammation

Research Article

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

Table 3

Overview of mRNA expression in intestinal biopsies from UC and CD patients. ↑, ↓, and =: increased, decreased, or unchanged mRNA levels respect to healthy controls, Mann-Whitney P < .05.
Ulcerative colitisCrohn’s disease
AffectedUnaffectedAffectedUnaffected
Mediators of mucosal damage
GZMB
iNOS
MMP-3
TIMP-1
Proinflammatory cytokines in affected areas only
IL-1
IL-4
IL-12(p35)
IL-12(p40)
IL-27(p28)
Cytokines in affected and unaffected areas
IFN
TNF
IL-6
IL-15WB /mRNA WB /mRNA WB /mRNA WB /mRNA
IL-18WB /mRNA WB /mRNA WB /mRNA WB /mRNA
IL-23(p19)
SOCS family
SOCS-2
SOCS-3
SOCS-4
SOCS-5
Regulatory cytokines
IL-10
TGF