Figure 2: U-IgM as prognostic marker No OD: no development of critical damage according to VDI during followup. OD: development of critical damage according to VDI. All patients in stable phase of the disease when the sample was taken (7 in remission and 8 with smouldering disease; 50 in remission and 17 with smouldering activity in the group who did not develop OD, presented as g IgM/mmole creatinine. The box plot shows median value, with 95% confidence interval.