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Mediators of Inflammation
Volume 2009 (2009), Article ID 817498, 13 pages
Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment
1Applied Mathematics Department, Universidad Complutense de Madrid, 28040 Madrid, Spain
2Haematology Department, Institute of Research of Hospital Santa Creu i Sant Pau, 08025 Barcelona, Spain
3Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Research of Hospital Santa Creu i Sant Pau, 08025 Barcelona, Spain
4Haematology Department, Complejo Hospitalario Virgen de la Salud, 45004 Toledo, Spain
5Centro de Salud La Estación, Talavera de la Reina, 45600 Toledo, Spain
6Research Laboratory, Fundación Jiménez Díaz, 28040 Madrid, Spain
Received 1 July 2009; Accepted 1 November 2009
Academic Editor: Eeva Moilanen
Copyright © 2009 Antonio Brú et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. J. Edelson and Z. A. Cohn, “Peroxidase mediated mammalian cell cytotoxicity,” Journal of Experimental Medicine, vol. 138, no. 1, pp. 318–323, 1973.
- R. A. Clark, S. J. Klebanoff, A. B. Einstein, and A. Fefer, “Peroxidase halide system: cytotoxic effect on mammalian tumor cells,” Blood, vol. 45, no. 2, pp. 161–170, 1975.
- J. J. Rinehart, P. Lange, B. J. Gormus, and M. E. Kaplan, “Human monocyte-induced tumor cell cytotoxicity,” Blood, vol. 52, no. 1, pp. 211–220, 1978.
- G. M. Shaw, P. C. Levy, and A. F. LoBuglio, “Human monocyte antibody dependent cell mediated cytotoxicity to tumor cells,” Journal of Clinical Investigation, vol. 62, no. 6, pp. 1172–1180, 1978.
- A. Slivka, A. F. LoBuglio, and S. J. Weiss, “A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity,” Blood, vol. 55, no. 2, pp. 347–350, 1980.
- S. J. Weiss and A. Slivka, “Monocyte and granulocyte-mediated tumor cell destruction,” Journal of Clinical Investigation, vol. 69, no. 2, pp. 255–262, 1982.
- F. Dallegri, F. Patrone, G. Frumento, and C. Sacchetti, “Antibody-dependent killing of tumor cells by polymorphonuclear leukocytes. Involvement of oxidative and nonoxidative mechanisms,” Journal of the National Cancer Institute, vol. 73, no. 2, pp. 331–339, 1984.
- F. Dallegri, G. Frumento, A. Ballestrero, R. Goretti, and F. Patrone, “Relationship between antibody-dependent tumour cell lysis and primary granule exocytosis by human neutrophils,” Clinical and Experimental Immunology, vol. 70, no. 2, pp. 479–483, 1987.
- A. Lichtenstein, M. Seelig, J. Berek, and J. Zighelboim, “Human neutrophil-mediated lysis of ovarian cancer cells,” Blood, vol. 74, no. 2, pp. 805–809, 1989.
- M. Katano and M. Torisu, “Neutrophil-mediated tumor cell destruction in cancer ascites,” Cancer, vol. 50, no. 1, pp. 62–68, 1982.
- D. J. Cameron, “A comparison of the cytotoxic potential in polymorphonuclear leukocytes obtained from normal donors and cancer patients,” Clinical Immunology and Immunopathology, vol. 28, no. 1, pp. 115–124, 1983.
- F. Lozupone, F. Luciani, M. Venditti, et al., “Murine granulocytes control human tumor growth in SCID mice,” International Journal of Cancer, vol. 87, no. 4, pp. 569–573, 2000.
- F. Dallegri, A. Ballestrero, L. Ottonello, and F. Patrone, “Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients,” Clinical and Experimental Immunology, vol. 77, no. 1, pp. 58–61, 1989.
- Y. Midorikawa, T. Yamashita, and F. Sendo, “Modulation of the immune response to transplanted tumors in rats by selective depletion of neutrophils in vivo using a monoclonal antibody: abrogation of specific transplantation resistance to chemical carcinogen-induced syngeneic tumors by selective depletion of neutrophils in vivo,” Cancer Research, vol. 50, no. 19, pp. 6243–6247, 1990.
- M. J. Alvarez, F. Prada, E. Salvatierra, et al., “Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity,” Cancer Research, vol. 65, no. 12, pp. 5123–5132, 2005.
- G. Biozzi, O. G. Ribeiro, A. Saran, et al., “Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse,” Carcinogenesis, vol. 19, no. 2, pp. 337–346, 1998.
- D. A. Maria, O. G. Ribeiro, K. F. Pizzocaro, et al., “Resistance to melanoma metastases in mice selected for high acute inflammatory response,” Carcinogenesis, vol. 22, no. 2, pp. 337–342, 2001.
- O. G. Ribeiro, D. A. Maria, S. Adriouch, et al., “Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response,” Journal of Leukocyte Biology, vol. 74, no. 4, pp. 497–506, 2003.
- O. G. Ribeiro, W. H. Cabrera, D. A. Maria, et al., “Genetic selection for high acute inflammatory response confers resistance to lung carcinogenesis in the mouse,” Experimental Lung Research, vol. 31, no. 1, pp. 105–116, 2005.
- J. R. Ostberg, B. R. Ertel, and J. A. Lanphere, “An important role for granulocytes in the thermal regulation of colon tumor growth,” Immunological Investigations, vol. 34, no. 3, pp. 259–272, 2005.
- N. Agrawal, C. Bettegowda, I. Cheong, et al., “Bacteriolytic therapy can generate a potent immune response against experimental tumors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 42, pp. 15172–15177, 2004.
- F. Avogadri, C. Martinoli, L. Petrovska, et al., “Cancer immunotherapy based on killing of Salmonella-infected tumor cells,” Cancer Research, vol. 65, no. 9, pp. 3920–3927, 2005.
- H. Suttmann, J. Riemensberger, G. Bentien, et al., “Neutrophil granulocytes are required for effective Bacillus Calmette-Guérin immunotherapy of bladder cancer and orchestrate local immune responses,” Cancer Research, vol. 66, no. 16, pp. 8250–8257, 2006.
- C. Maletzki, M. Linnebacher, B. Kreikemeyer, and J. Emmrich, “Pancreatic cancer regression by intratumoural injection of live Streptococcus pyogenes in a syngeneic mouse model,” Gut, vol. 57, no. 4, pp. 483–491, 2008.
- Z. Cui, M. C. Willingham, A. M. Hicks, et al., “Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 11, pp. 6682–6687, 2003.
- A. M. Hicks, G. Riedlinger, M. C. Willingham, et al., “Transferable anticancer innate immunity in spontaneous regression/complete resistance mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 20, pp. 7753–7758, 2006.
- A. M. Hicks, M. C. Willingham, W. Du, C. S. Pang, L. J. Old, and Z. Cui, “Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice,” Cancer Immunity, vol. 6, pp. 1–9, 2006.
- M. Jaganjac, M. Poljak-Blazi, K. Zarkovic, R. J. Schaur, and N. Zarkovic, “The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma,” Cancer Letters, vol. 260, no. 1-2, pp. 180–186, 2008.
- P. Musiani, A. Allione, A. Modica, et al., “Role of neutrophils and lymphocytes in inhibition of a mouse mammary adenocarcinoma engineered to release IL-2, IL-4, IL-7, IL-10, IFN-, IFN-, and TNF-,” Laboratory Investigation, vol. 74, no. 1, pp. 146–157, 1996.
- B. M. Babior, “Phagocytes and oxidative stress,” American Journal of Medicine, vol. 109, no. 1, pp. 33–44, 2000.
- A. K. Lichtenstein, T. Ganz, M. E. Selsted, and R. I. Lehrer, “Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins,” Cellular Immunology, vol. 114, no. 1, pp. 104–116, 1988.
- K. P. M. Van Kessel, J. A. G. Van Strijp, H. J. Van Kats-Renaud, L. A. M. Miltenburg, A. C. Fluit, and J. Verhoef, “Uncoupling of oxidative and non-oxidative mechanisms in human granulocyte-mediated cytotoxicity: use of cytoplasts and cells from chronic granulomatous disease patient,” Journal of Leukocyte Biology, vol. 48, no. 4, pp. 359–366, 1990.
- M.-B. Hevin, B. Friguet, and R. M. Fauve, “Inflammation and anti-tumor resistance. V. Production of a cytostatic factor following cooperation of elicited polymorphonuclear leukocytes and macrophages,” International Journal of Cancer, vol. 46, no. 3, pp. 533–538, 1990.
- A. L. Kindzelskii and H. R. Petty, “Early membrane rupture events during neutrophil-mediated antibody-dependent tumor cell cytolysis,” Journal of Immunology, vol. 162, no. 6, pp. 3188–3192, 1999.
- M. Zivkovic, M. Poljak-Blazi, G. Egger, S. B. Sunjic, R. J. Schaur, and N. Zarkovic, “Oxidative burst and anticancer activities of rat neutrophils,” BioFactors, vol. 24, no. 1–4, pp. 305–312, 2005.
- H. Horner, C. Frank, C. Dechant, et al., “Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity,” Journal of Immunology, vol. 179, no. 1, pp. 337–345, 2007.
- A. Brú, J. M. Pastor, I. Fernaud, I. Brú, S. Melle, and C. Berenguer, “Super-rough dynamics on tumor growth,” Physical Review Letters, vol. 81, no. 18, pp. 4008–4011, 1998.
- A. Brú, S. Albertos, J. L. Subiza, J. L. García-Asenjo, and I. Brú, “The universal dynamics of tumor growth,” Biophysical Journal, vol. 85, no. 5, pp. 2948–2961, 2003.
- A. Brú, S. Albertos, J. L. García-Asenjo, and I. Brú, “Pinning of tumoral growth by enhancement of the immune response,” Physical Review Letters, vol. 92, no. 23, Article ID 238101, 4 pages, 2004.
- A. Brú, S. Albertos, F. García-Hoz, and I. Brú, “Regulation of neutrophilia by granulocyte colony-stimulating factor: a new cancer therapy that reversed a case of terminal hepatocellular carcinoma,” Journal of Clinical Research, vol. 8, no. 9–13, pp. 9–13, 2005.
- Y. B. Su, A. J. Vickers, M. J. Zelefsky, et al., “Double-blind, placebo-controlled, randomized trial of granulocyte-colony stimulating factor during postoperative radiotherapy for squamous head and neck cancer,” Cancer Journal, vol. 12, no. 3, pp. 182–188, 2006.
- B. I. Rini, L. Fong, V. Weinberg, B. Kavanaugh, and E. J. Small, “Clinical and immunological characteristics of patients with serologic progression of prostate cancer achieving long-term disease control with granulocyte-macrophage colony-stimulating factor,” Journal of Urology, vol. 175, no. 6, pp. 2087–2091, 2006.
- U. Bottoni, P. Bonaccorsi, V. Devirgiliis, et al., “Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF,” Japanese Journal of Clinical Oncology, vol. 35, no. 9, pp. 507–513, 2005.
- T. A. Springer, “Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration,” Annual Review of Physiology, vol. 57, pp. 827–872, 1995.
- J. Solá, L. Vila, L. Puig, and J. M. de Moragas, “Metabolism of exogenous arachidonic acid by polymorphonuclear leukocytes from psoriatic patients,” Archives of Dermatological Research, vol. 283, no. 2, pp. 77–80, 1991.
- P. M. Davison, K. Bensch, and M. A. Karasek, “Isolation and growth of endothelial cells from the microvessels of the newborn human foreskin in cell culture,” Journal of Investigative Dermatology, vol. 75, no. 4, pp. 316–321, 1980.
- K. Sakamoto, T. Masuda, S. Mita, et al., “Interleukin-8 is constitutively and commonly produced by various human carcinoma cell lines,” International Journal of Clinical & Laboratory Research, vol. 22, no. 1–4, pp. 216–219, 1992.
- H. Schaider, M. Oka, T. Bogenrieder, et al., “Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8,” International Journal of Cancer, vol. 103, no. 3, pp. 335–343, 2003.
- S. K. Ahuja and P. M. Murphy, “The CXC chemokines growth-regulated oncogene (GRO) , GRO, GRO, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor,” Journal of Biological Chemistry, vol. 271, no. 34, pp. 20545–20550, 1996.
- H. Petering, O. Götze, D. Kimmig, R. Smolarski, A. Kapp, and J. Elsner, “The biologic role of interlekin-8:functional analysis and expression of CXCR1 and CXCR2 on human eosinophils,” Blood, vol. 93, pp. 694–702, 1999.
- A. Wuyts, P. Proost, J.-P. Lenaerts, A. Ben-Baruch, J. Van Damme, and J. M. Wang, “Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neuhrophil attractant-78,” European Journal of Biochemistry, vol. 255, no. 1, pp. 67–73, 1998.
- D. Cilloni, G. Martinelli, F. Messa, M. Baccarani, and G. Saglio, “Nuclear factor B as a target for new drug development in myeloid malignancies,” Haematologica, vol. 92, no. 9, pp. 1224–1229, 2007.
- C. Van Waes, “Nuclear factor-B in development, prevention, and therapy of cancer,” Clinical Cancer Research, vol. 13, no. 4, pp. 1076–1082, 2007.
- A. E. Koch, P. J. Polverini, S. L. Kunkel, et al., “Interleukin-8 as a macrophage-derived mediator of angiogenesis,” Science, vol. 258, no. 5089, pp. 1798–1801, 1992.
- D. R. Smith, P. J. Polverini, S. L. Kunkel, et al., “Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma,” Journal of Experimental Medicine, vol. 179, no. 5, pp. 1409–1415, 1994.
- J. M. Wang, G. Taraboletti, K. Matsushima, J. Van Damme, and A. Mantovani, “Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8,” Biochemical and Biophysical Research Communications, vol. 169, no. 1, pp. 165–170, 1990.
- R. K. Singh, M. Gutman, R. Radinsky, C. D. Bucana, and I. J. Fidler, “Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice,” Cancer Research, vol. 54, no. 12, pp. 3242–3247, 1994.
- C. L. Galligan and B. L. Coomber, “Effects of human IL-8 isoforms on bovine neutrophil function in vitro,” Veterinary Immunology and Immunopathology, vol. 74, no. 1-2, pp. 71–85, 2000.
- B. Metzner, M. Barbisch, F. Parlow, E. Kownatzki, I. Schraufstatter, and J. Norgauer, “Interleukin-8 and GRO prime human neutrophils for superoxide anion production and induce up-regulation of N-formyl peptide-receptors,” Journal of Investigative Dermatology, vol. 104, no. 5, pp. 789–791, 1995.
- N. Mukaida, “Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation,” International Journal of Hematology, vol. 72, no. 4, pp. 391–398, 2000.
- J. M. Cook-Mills and T. L. Deem, “Active participation of endothelial cells in inflammation,” Journal of Leukocyte Biology, vol. 77, no. 4, pp. 487–495, 2005.
- L. Yang, R. M. Froio, T. E. Sciuto, A. M. Dvorak, R. Alon, and F. W. Luscinskas, “ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF--activated vascular endothelium under flow,” Blood, vol. 106, no. 2, pp. 584–592, 2005.
- T. M. Carlos and J. M. Harlan, “Leukocyte-endothelial adhesion molecules,” Blood, vol. 84, no. 7, pp. 2068–2101, 1994.
- A. B. Van Spriel, J. H. W. Leusen, M. van Egmond, et al., “Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation,” Blood, vol. 97, no. 8, pp. 2478–2486, 2001.
- A. B. Van Spriel, H. H. van Ojik, A. Bakker, M. J. H. Jansen, and J. G. J. van de Winkel, “Mac-1 (CD11b/CD18) is crucial for effective fc receptor-mediated immunity to melanoma,” Blood, vol. 101, no. 1, pp. 253–258, 2003.
- A. Mantovani, P. Romero, A. K. Palucka, and F. M. Marincola, “Tumour immunity: effector response to tumour and role of the microenvironment,” The Lancet, vol. 371, no. 9614, pp. 771–783, 2008.
- E. Di Carlo, G. Forni, P. Lollini, M. P. Colombo, A. Modesti, and P. Musiani, “The intriguing role of polymorphonuclear neutrophils in antitumor reactions,” Blood, vol. 97, no. 2, pp. 339–345, 2001.
- E. Di Carlo, G. Forni, and P. Musiani, “Neutrophils in the antitumoral immune response,” Chemical Immunology and Allergy, vol. 83, pp. 182–203, 2003.
- O. J. Finn, “Cancer immunology,” New England Journal of Medicine, vol. 358, no. 25, pp. 2704–2715, 2008.
- E. Wang, A. Worschech, and F. M. Marincola, “The immunologic constant of rejection,” Trends in Immunology, vol. 29, no. 6, pp. 256–262, 2008.
- J. C. Souto, L. Vila, and A. Brú, “Polymorphonuclear neutrophils and cancer. Intense and sustained neutrophilia as a treatment against solid tumors,” Medicinal Research Reviews, December 4 [Epub ahead of print], 2009.