Disease Gene expression in affected tissue Tissue Array type References RA CD9↑
, CD20↑, CD69 ↑, T cell receptor
and
chain ↑, MMP1 ↑, MMP3 ↑, IP-10↑, CXCR4 ↑, SDF1 ↑, STAT-1 ↑, IL-15 ↑, c-fos ↑, IL-6R
↑, IL-6R
↑ Synovial tissue from RA and Osteo-arthritis patients cDNA microarrays, 18 000 probes [25 ] IL-2 ↑, IL-4 ↑, IL-13 ↑, IL-17 ↑, EGF ↑, bFGF ↑, IL-1 ↑, IL-15 ↑ Synovial fluid from early onset RA and other early synovitis patients Multiplex bead-based system, Biosource International, Camarillo, Calif, USA [26 ] CD14 ↑, defensin
-1 and
-3 ↑, ribonuclease 2 ↑, S100 A8 and A12 ↑, HLA-DQB1 ↓ PBMC from RA and osteoarthritis patients Oligonucleotide microarrays, 10 000 Probes [29 ] CD14 ↑, CD163 ↑, S100 A12↑, CD13 ↑, chemokine (C-C motif) receptor 1 ↑, IL-1Ra ↑, CD72 ↓ , CD79b ↓ , PKC
↓ PBMC from RA patients and healthy controls U95A microarrays, Affymetrix, 12 600 probes sets [30 ] CIA Bsg ↑, Anxa5 ↑, Mmp3 ↑, Mmp9 ↑, Jup ↑, Tgfb1 ↑, Il2rg, Cd53 ↑, c-fos ↓ , Sdc4 ↓ , Prg2 ↓ Inflamed paws of mice with CIA and control mice Mu11K oligonucleotide microarrays, Affymetrix, 11 000 probe sets [31 ] MS IL-1R ↑, IL-8R2 ↑, IL-11α ↑, L-17 ↑, TNFR ↑, Filamin ↑, SMAD6 ↑, MAG ↓ , PLP1↓ Brain biopsies from MS patients and controls HuGeneFL oligonucleotide microarrays, Affymetrix, 7000 probe sets [32 ] ICAM1↑, CDC42↑, RIPK2↑, IL1R2↑, CXCL2↑, ↑ MAD ↑, CDC25B ↓ , DAXX ↓ , BCL2 ↓ , NFATC3↓ , EGF ↓ , E2F5 ↓ PBMC from MS patients and controls 1258 element cDNA microarrays [33 ] BNIP3 ↑, 2’ 5’ OAS ↑, STAT1↑, IFN-induced 17 kDa ↑, TRAIL ↑, CD69↓ , c-jun ↓ , c-fos ↓ , flt3 ligand ↓ , Iκ B
↓ , IL-8 ↓ , IL-17R ↓ , MKP1 ↓ , PCNA ↓ PBMC of MS patients before and under treatment with IFN-
Mini-Lymphochip cDNA microarrays, 12 600 probes [34 ] MxA/MX1↑, IRF7 ↑, MX2 ↑, OAS2 ↑, IL15 ↑, IL1RN ↑, IL1RA ↑, CCR1 ↑, ECGF1 ↑, EEF1D ↓ , RPL5 ↓ PBMC of MS patients before and after treatment HuFL microarrays, Affymetrix, 8000 probe sets [35 ] EAE Il1rn ↑, Tnfrsf1a ↑, Ifnb1 ↑, interferon-induced 15 kD protein ↑, interferon-inducible protein 1-8D ↑, Ccl5 ↑, Scya-9, Cxcl10 ↑, Tcrb ↑, Cd53, Lfa-1 (Itgb2) ↑, Flt3 ↓ , Glud1 ↓ , Ntsr2 ↓ Spinal cord biopsies from EAE mice and controls Mu11K oligonucleotide microarrays, Affymetrix 11 000 probe sets [36 ]