Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Figure 1

Concentration-response curve of the proliferation induced by angiotensin (Ang) II in aortic vascular smooth muscle cells (VSMCs) obtained from Wistar rats. Values are the mean $\pm$ SEM (n = 10–15). Differences between groups were analysed by one-way ANOVA followed by Dunnet’s test. **$P<.01$, ***$P<.001$ versus control response in unstimulated cells.