Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Figure 4

Effect of leptin activation of Akt and STAT3 and iNOS expression in aortic VSMCs. Bar graphs show the differences in the time course of Akt (a) and STAT3 (b) activation/phosphorylation as well as iNOS (c) protein expression in leptin (10 nmol/L)-stimulated aortic VSMCs from Wistar and SHR. Data are expressed as mean $\pm$ SEM ($n$ = 10). Differences between groups were analysed by two-way ANOVA. In case of interaction between factors (strain and time of leptin stimulation), differences between groups were analysed by one-way ANOVA followed by Dunnet’s test *P < .05, **P < .01 versus unstimulated cells.

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