Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis
Table 5
Correlations between the serum cytokines, chemokines, and growth factor concentrations in the total cohort of RA patients ().
IL-1β
IL-1Ra
IL-2
IL-4
IL-6
IL-7
IL-8
IL-10
IL-12
IL-17
G-CSF
GM-CSF
IFN-γ
TNF
0.85
0.64
0.77
0.86
0.59
0.50
0.23
0.70
0.68
0.52
0.75
0.79
0.81
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
.0062
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
IFN-γ
0.86
0.66
0.80
0.95
0.56
0.73
0.31
0.72
0.79
0.50
0.81
0.82
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
.0002
<.0001
<.0001
<.0001
<.0001
<.0001
GM-CSF
0.86
0.72
0.89
0.87
0.59
0.50
0.26
0.77
0.67
0.48
0.79
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
.0015
<.0001
<.0001
<.0001
<.0001
G-CSF
0.77
0.62
0.71
0.86
0.47
0.49
0.22
0.63
0.55
0.48
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
.0083
<.0001
<.0001
<.0001
IL-12
0.84
0.53
0.79
0.82
0.45
0.84
0.35
0.90
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
IL-10
0.80
0.68
0.76
0.73
0.69
0.63
0.23
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
.0237
IL-7
0.61
0.34
0.61
0.70
0.35
<.0001
<.0001
<.0001
<.0001
<.0001
IL-4
0.88
0.70
0.81
<.0001
<.0001
<.0001
IL-2
0.83
0.77
<.0001
<.0001
IL-1Ra
0.79
<.0001
*For each pair of values, the correlation coefficient () is uppermost with the corresponding value underneath. Strong correlations () are highlighted in bold type, and moderate and weak correlations in plain type.
