Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis

Table 7

Correlations of VEGF with autoantibodies, circulating cytokines, and X-ray scores in the total cohort (𝑛=140) and HDA group (𝑛=63).

	Total	HDA
	𝑟(𝑝)	𝑟(𝑝)
RF	0.44 (0.0014)	0.60 (0.0023)
SAA	ns	ns
CRP	ns	ns
aMCV	ns	0.59 (0.0023)
aCCP	ns	0.67 (0.0003)
IL-1𝛽	0.29 (0.0433)	0.48 (0.0190)
IL-1Ra	ns	0.41 (0.0474)
IL-2	0.40 (0.0038)	0.61 (0.0014)
IL-4	0.36 (0.0098)	0.65 (0.0006)
IL-7	0.55 (<0.0000)	0.65 (0.0006)
IL-8	ns	0.41 (0.0448)
IL-10	0.38 (0.0072)	0.46 (0.0246)
IL-12	0.46 (0.0009)	0.60 (0.0021)
G-CSF	0.31 (0.0306)	0.55 (0.0052)
GM-CSF	0.37 (0.0086)	0.69 (0.0002)
IFN-γ	0.37 (0.0082)	0.66 (0.0004)
TNF	ns	0.53 (0.0078)
CCL2	0.40 (0.0044)	ns
CCL4	ns	0.56 (0.0044)
Larsen	ns	0.42 (0.0409)

RF: Rheumatoid factor, SAA: Serum amyloid A, CRP: C-reactive protein, aCCP: anticyclic citrullinated peptide antibodies, aMCV: Antimodified citrullinated vimentin antibodies.
ns: not significant.