Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NFB-Dependent Pathway
Figure 5
Direct comparison of cholesterol synthase inhibitors, angiotensin receptor blockers, total extract of Rhizoma coptidis (dilution ), and berberine (dilution 10−4 mol) on transcription factor activity of AP-1 (a) and NF B (b). Exposure time of all substrates was 240 min. AP-1: activated protein-1, NF B: nuclear factorκB, Co: LPS-stimulated control cells, RC:Rhizoma coptidis, Be: berberine, Ros: 10−6 mol rosuvastatin, Flu: 10−6 mol fluvastatin, Tel: 10−5 mol telmisartan, Olm: 10−5 mol olmesartan, and CC: cold competition. .