Research Article

Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NF B-Dependent Pathway

Figure 5

Direct comparison of cholesterol synthase inhibitors, angiotensin receptor blockers, total extract of Rhizoma coptidis (dilution 1:5), and berberine (dilution 10−4 mol) on transcription factor activity of AP-1 (a) and NFκ B (b). Exposure time of all substrates was 240 min. AP-1: activated protein-1, NFκ B: nuclear factorκB, Co: LPS-stimulated control cells, RC:Rhizoma coptidis, Be: berberine, Ros: 10−6 mol rosuvastatin, Flu: 10−6 mol fluvastatin, Tel: 10−5 mol telmisartan, Olm: 10−5 mol olmesartan, and CC: cold competition. *P<.005, **P<.001.
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194896.fig.005b
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