Role of Meconium and Hypoxia in Meconium Aspiration-Induced Lung Injury in Neonatal Rabbits
Table 3
(a) Expression of TNFα, IL-1β, IL-6, and IL-10 cytokines after saline, meconium, or milk instillation (in pg/ml).
Sal 8 hrs
Mec 4 hrs
Mec 8 hrs
Mec 24 hrs
Milk 4 hrs
Milk 8 hrs
Milk 24 hrs
TNFα ()
IL-1β
IL-6 ()
IL-10
Changes in cytokine levels within the saline-treated or milk-treated groups were not significant. In meconium group, cytokine levels increased significantly at 8 and 24 hrs.
(b) Expression of TNFα, IL-1β, IL-6, and IL-10 cytokines after 15-minute treatment in hypoxic or hyperoxic conditions.
Cytokines (pg/ml)
Saline 8 hrs
Hypoxia 15 min
Hyperoxia 15 min
TNFα ()
IL-1β
IL-6 ()
IL-10
Cytokine levels in hypoxic or hyperoxic conditions were elevated. However, a significant increase was observed only for TNFα and IL6 expressions for both hypoxic and hyperoxic groups compared to saline-instilled group.