High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.

Figure 2

12(S)-hydroxyeicosatetraenoic acid concentrations in sciatic nerve ((a), (b)) and spinal cord ((c), (d)) after 16-week ((a) and (c)) and 23-week ((b) and (d)) feedings with normal chow or high-fat diet with or without PMI-5011. NC: normal chow, HF: high fat diet, T: treatment. $\text{Mean}\pm \text{SEM}\text{,}$$n=9\text{–}13$ per group. ${}^{**}$$P<.01$ versus mice fed NC; ${}^{\S ,\S \S }P<.05$ and $<.01$ versus the baseline value (16-wk time point); ${}^{\pounds }P<.05$ versus mice fed NC (16-wk time point); ${}^{\#,\#\#}P<.05$ and $<.01$ versus untreated mice fed HFD (23-wk time point).

(a)

(b)

(c)

(d)