High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.
Table 3
Variables of small sensory fiber neuropathy in normal chow and high fat diet-fed mice maintained with and without PMI-5011 treatment.
Groups
NC
HFD
Variables
Baseline (prior to the beginning of HFD feeding)
Paw withdrawal latency, s−1
Tail flick response latency, s−1
Tactile withdrawal threshold, g
Mechanical withdrawal threshold, g
16-wk time point (prior to PMI-5011 treatment)
Paw withdrawal latency, s−1
Tail flick response latency, s−1
Tactile withdrawal threshold, g
Mechanical withdrawal threshold, g
23-wk time point (final measurements)
Paw withdrawal latency, s−1
Tail flick response latency, s−1
Tactile withdrawal threshold, g
Mechanical withdrawal threshold, g
Data are expressed as per group. NC: normal chow; T: treatment; HFD: high fat diet; and versus corresponding controls; and versus the baseline value (16-wk time point); and versus mice fed NC (16-wk time point); and versus untreated mice fed HFD (23-wk time point).