Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model

Table 1

The preventive versus curative effect of Celecoxib on bladder cancer: quantitative evaluation of urothelium lesions.

Macroscopy	Control	CEL	BBN	CEL+BBN-P	BBN+CEL-C
(quantitative)	(𝑛=8)	(𝑛=8)	(𝑛=20)	(𝑛=8)	(𝑛=8)
Tumor number (%)
% of rats with tumor	0	0	(13 in 20) 65.0%	(1 in 8) 12.5%	(6 in 8) 75.0%
Nr tumors/rat with tumor	0	0	1.2±0.1 (16 in 13)	4.0^† (4 in 1)	1.8±0.5 (11 in 6)
Tumor volume (mm^3)
Mean/rat with tumor	0	0	138.5±7.5 (in 13)	21.2^† (in 1)	59.8±20.8 (in 6)
Mean/tumor	0	0	112.5±6.4 (in 16)	5.3±0.4 (in 4)	35.9±14.8 (in 11)

^†Represents only 1 rat in 8 of the group (s.e.m. in not applicable). Values are mean ± SEM, excepting for % of rats with tumor. BBN: N-butyl-N-(4-hydroxybutyl) nitrosamine; CEL: celecoxib; C: curative; P: preventive.