Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats

Figure 1

Body mass (a) and food intake (b) in control rats on standard diet (CN $=$▲), high-fat diet (SHF $=$ ■), and food restriction (FR $=$♦), and in arthritic rats on standard diet (AA-N $=$ ∆), high-fat diet (AA-SHF $=$ □), and food restriction (AA-FR$=$ ◊) in selected days after cFA inoculation. Values for food intake are presented as means of 2 cages (4 rats per cage). Statistical significance between the body mass values in arthritic rats and their corresponding controls on the same dietary regime: ${}^{*}P<.05\text{,}$${}^{**}P<.01\text{,}$${}^{***}P<.001$. Significant difference between AA-N and AA-SHF: ${}^{†}P<.05$. First day of significant differences: CN versus SHF ${}^{\times }P<.05$, FR versus CN ${}^{\text{a}}P<.05$, FR versus SHF ${}^{\text{b}}P<.001$, AA-FR versus AA-N ${}^{\#\#\#}P<.001$, and AA-FR versus AA-SHF ${}^{+++}P<.001$. Effects of dietary interventions on the severity of arthritis expressed by arthrogram score (c). Significant difference between AA-FR and AA-N: ${}^{*}P<.05\text{,}$${}^{***}P<.001$; significant difference between AA-FR and AA-SHF: ${}^{+++}P<.001$; significant difference between AA-SHF and AA-N: ${}^{†}P<.05$.

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