Release of Danger Signals during Ischemic Storage of the Liver: A Potential Marker of Organ Damage?

Table 1

Group distribution.

Damage type	Strain	Observation interval	Observation time	Effluent	Liver tissue
CI	Lewis (𝑛=6)	1 h	24 h	HMGB1; MIF	Histology
M+CI	Lewis (𝑛=6)	1 h	24 h	AST; ALT	HMGB1 IHC
WI	Lewis (𝑛=6)	0,5 h	6 h
M+CI	Lewis (𝑛=6)	0,5 h	6 h
CI	BN (𝑛=6)	1 h	24 h

CI, cold ischemia; WI, warm ischemia; M, mechanical stress; HMGB1, high mobility group box-1; MIF, macrophage migration inhibitory factor; IHC, immunohistochemistry; AST, aspartate aminotransferase; ALT, alanine transaminase.