Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages

Figure 1

Splenic macrophages obtained from young and aged WT and IL-6 KO mice were cultured for 18 hours with LPS (100 ng/ml). Supernatants collected were assayed for TNF$\alpha$ (a), IL-1$\beta$ (b), IL-6 (c), and IL-12 (d), by ELISA. Data are shown as mean ± SEM of 4-5 mice per group. ${}^{*}P<.05$ from young WT. ${}_{}{}^{\#}P<.05$ from young WT. ${}^{†}P<.05$ from young IL-6 KO. ${}^{@}P<.05$ from aged WT.

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