Proinflammatory Mediators of Toxic Shock and Their Correlation to Lethality

Figure 5

Serum levels of TNF$\alpha$, IL-1, IL-6, IFN$\gamma$, IL-2, MIP-2, and MCP-1 of mice treated with SEB + LPS (a) 8 hours after SEB administration (b) 21 hours after SEB administration by survival status. Points represent the geometric mean ± standard deviation (SD) for survivors and nonsurvivors of mice treated with SEB + LPS. SEB + LPS group consisted of mice treated with 1 $\mu$g SEB + 80 $\mu$g LPS, 1 $\mu$g SEB + 60 $\mu$g LPS, 10 $\mu$g SEB + 10 $\mu$g LPS, 30 $\mu$g SEB + 10 $\mu$g LPS, 60 $\mu$g SEB + 10 $\mu$g LPS, 100 $\mu$g SEB + 10 $\mu$g LPS, 30 $\mu$g SEB + 1 $\mu$g LPS, and 100 $\mu$g SEB + 1 $\mu$g LPS. Values represent the geometric mean ± SD for each group. The “${}^{*}$” indicates P <  .05 when survivors were compared with nonsurvivors of toxic shock.

(a)

(b)