Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)

Figure 1

Glycaemic and insulinaemic profiles. Serum Glycaemia (a), HbA1c (b), insulinaemia (c) and insulin resistance (HOMA-IR) index (d), for the control ($+/+$) and diabetic (fa/fa) ZDF rats, in the initial and final times (6 weeks of vehicle or 10 mg/kg BW/day sitagliptin treatment). Comparisons between groups ($n=8$ each): a - ZDF (fa/fa) versus ZDF ($+/+$) and b - with sita versus without sita; $P<.05\text{,}$$P<.01$ and $P<.001$ for one, two or three letters, respectively. HOMA-IR, homeostasis model assessment—insulin resistance.

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