Role of Bone Marrow-Derived Monocytes/Macrophages in the Repair of Mucosal Damage Caused by Irradiation and/or Anticancer Drugs in Colitis Model
Figure 5
Administration of bone marrow cells (BMC) enhanced healing mucosal damage. (a) Mucosal damage was induced by the AA treatment and the additional administration of 5-FU (100 mg/kg) on day 0 (AA + 5-FU). BMC were injected into AA + 5-FU mice on day 1. In the Sham-operated group (control), saline was injected into colon instead of AA. Administration of BMC enhanced healing mucosal damage in AA + 5-FU mice on day 7 significantly. (b) Comparison of changes in body weight between each group. Although AA + 5-FU mice significantly reduce their body weight, BMT rescued the body weight loss from day 3. Values represent mean ± SEM. Data were analyzed using the Tukey method. *, AA + 5-FU versus AA + 5-FU + BMT.
