DAMPening Inflammation by Modulating TLR Signalling

Figure 2

Endogenous ligand recognition by TLRs. The co-receptor(s) and accessory molecule(s) required by DAMPs for recognition by TLR(s) and subsequent cellular activation are shown. (a) TLRs localised on the plasma membrane; (b) TLRs resident in intracellular compartments. (${}^{*}$)HMGB1 may require MD-2 and CD14 for TLR4 activation (see [96]).

(a)

(b)