DAMPening Inflammation by Modulating TLR Signalling

Table 2

Targeted deletion of DAMPs protects from experimental disease. Mice which do not express certain DAMPs exhibit reduced symptoms of inflammatory disease or tumor metastasis in vivo.

DAMP	Disease Model	Effect of deletion	Refs
Biglycan	Renal inflammation (unilateral ureteral obstruction)	Reduced kidney damage	[87]
	Sepsis (LPS or zymosan)	Protected from lethality	[23, 87]
FNEDA	Atherosclerosis (Apo E deficient, high fat diet)	Reduced lesion size, number and macrophage infiltration	[139]
MRP8/MRP14	Abdominal sepsis (E. coli)	Reduced bacterial dissemination, systemic inflammation, liver damage	[140]
	Arterial injury (femoral wire insertion)	Reduced inflammatory cell infiltration and neotintimal formation	[141]
	Atherosclerosis (Apo E deficient, high fat diet)	Attenuated atherosclerotic lesions and macrophage accumulation in plaques	[141]
	Cerebral ischemia (cerebral artery occlusion)	Reduced lesion volume, brain swelling and inflammatory cell infiltration	[142]
	Lethal sepsis (LPS )	Protects from lethality	[143]
	Vasculitis (cytokine induced)	Reduced neutrophil accumulation and lesion severity	[141]
Tenascin-C	Destructive joint inflammation (antigen induced arthritis)	Protected from joint erosion and tissue destruction	[24]
	Tumorigenesis (cross with MMTV/PyV mice)	Induced smaller tumor nests	[144]