|
| DAMP | Disease Model | Mechanism of blockade | Refs |
|
| HA | Lung inflammation (bleomycin) | Over expression of HA synthase improved survival and decreased apoptosis | [145] |
| Sepsis (LPS) | High MW HA reduced lung neutrophil infiltration and cytokine synthesis | [146] |
|
| HMGB1 | Brain injury (transient ischemia) | mAb reduced infarct size and severity, locomotor function, cytokine synthesis | [130] |
| Colitis (DSS, TNBS) | pAb, ethyl pyruvate ameliorated disease, reduced cytokine synthesis, associated tumors | [147, 148] |
| Lung inflammation (LPS) | pAb decreased neutrophils, lung edema | [136, 138] |
| Lung injury (ventilator) | Ab improved oxygenation, neutrophil influx, cytokine synthesis | [149] |
| Hepatic ischemia reperfusion injury | pAb decreased liver damage | [135] |
| Acute pancreatitis (duodenal loop closure) | pAb improved pancreas and lung damage, aggravated bacterial translocation to pancreas | [150] |
| Hemorrhagic shock (blood withdrawal) | pAb improved survival, ameliorated ileal permeability, decreased serum cytokines | [151] |
| Hemorrhagic lung injury (cyclo-phosphamide) | pAb reduced pulmonary edema, neutrophil accumulation, lung permeability | [152] |
| Sepsis (LPS, E. Coli, cecal ligation and puncture) | pAb, mAb, DNA binding box A protected from/reversed lethality, rescues taste aversion | [114, 129, 153–155] |
| Ethyl pyruvate, stearoyl lysophosphatidylcholine, nicotine (inhibit secretion) protected from lethality | [156–158] |
| Neural ant-inflammatory peptides vasoactive intestinal peptide and urocortin rescue lethality | [159] |
| Cisplatin (nuclear sequestration of HMGB1) protected from lethality | [160] |
| Rheumatoid arthritis (Collagen) | pAb, DNA binding box A reduced severity of established joint disease | [161] |
|
| HSP90 | Rheumatoid arthritis (Collagen, adjuvant) | SNX-7081 (inhibitor) ameliorated disease, joints returned to normal | [162] |
| Tumorigenesis (nude mice) | BX-2819 (inhibitor) inhibited tumor growth | [163] |
|
| Neutrophil elastase | Acute lung injury (LPS induced) | Sivelestat or L-658,758 (inhibitors) reduced HMGB levels and lung damage | [164, 165] |
| Colitis (dextran) | ONO-5046 (inhibitor) reduced disease severity | [166] |
| Rheumatoid arthritis (Collagen) | ONO-5046 (inhibitor) reduced incidence and severity of disease, ablated cartilage destruction | [167] |
| Hepatic ischemia reperfusion injury | GW311616A (inhibitor) ameliorated liver damage, decreased neutrophil infiltration | [168] |
|
| Serum amyloid A | Tumorigenesis (LLC inoculation) | pAb reduced lung metastasis | [169] |
|
| Versican | Tumorigenesis (LLC inoculation) | siRNA reduced lung metastasis | [25] |
|
