Targeting TLR/IL-1R Signalling in Human Diseases

Figure 1

Structure of TIR domains. Sequence alignment of the TIR domains of human TLR1, TLR2, and TLR10 was performed by the ClustalW2 software. Identical residues are indicated by asterisks, while conservative or semi conservative substitutions are indicated by double-dots and single-dot, respectively. The TIR domain contains three highly conserved motifs denoted Box 1, 2, and 3 [10] that are shown in open boxes. Grey bars indicate the secondary structure of TIR domains, that are composed of five $\beta$-strands (from $\beta$A to $\beta$E) alternated with five $\alpha$-helices (from $\alpha$A to $\alpha$E) connected by eight loops.