Targeting TLR/IL-1R Signalling in Human Diseases

Figure 4

Chemical Structure of TIR BB-Loop Mimetic Compounds. AS1 (a), EM77 (b), and EM110 (c) inhibit the association between IL-1R and MyD88 [64, 65]. ST2825 (d) inhibits MyD88 homodimerization and its interaction with IRAK1 and IRAK4 [66].

(a)

(b)

(c)

(d)