Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells
Figure 2
IL-2 and IL-15 augment IFN-γ expression by phosphoantigen-stimulated Vγ9Vδ2 T cells. (a) Representative dot plots showing IFN-γ expression by Vγ9 cells 4 hours after stimulation with IPP (10 μM) or HMB-PP (10 nM), in the absence or presence of 50 U/mL IL-2 or 10 ng/mL IL-15. Plots are representative of 8 independent studies. Numbers in the plots indicate the percentages of Vγ9− (left) and Vγ9+ (right) T cells that produce each cytokine. (b) Mean (± SEM) percentages () of Vγ9 cells expressing IFN-γ after stimulation with various concentrations of IPP or HMB-PP, in the absence and presence of IL-2 and IL-15.
