Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of ob/ob Mice

Figure 1

Leptin reduces TBARS concentrations in ob/ob mice. Thiobarbituric acid reactive substances (TBARS) presented as concentrations of malondialdehyde (MDA $\mu$M) in serum (a) and gastrocnemius muscle (MDA $\mu$M/mg prot) (b) of wild type (open), control ob/ob (closed), pair-fed ob/ob (gray) and leptin-treated ob/ob (striped) mice ($n=5$ per group). Data are expressed as $\text{mean}\pm \text{SEM}\text{.}$${}^{*}P<.05$ and ${}^{**}P<.01$ by Kruskal-Wallis followed by Mann Whitney’s U test.

(a)

(b)