Mediators of Inflammation
Volume 2010 (2010), Article ID 958403, 6 pages
doi:10.1155/2010/958403
Research Article

Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents

1Department of Internal Medicine I, Friedrich-Schiller-University, Erlanger Allee 101, 07747 Jena, Germany
2Department of Medicine, Center for Molecular Medicine, Karolinska Institute, 17176 Stockholm, Sweden
3Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany

Received 4 October 2009; Accepted 17 November 2009

Academic Editor: Oreste Gualillo

Copyright © 2010 Christian Jung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. L. Ogden, M. D. Carroll, L. R. Curtin, M. A. McDowell, C. J. Tabak, and K. M. Flegal, “Prevalence of overweight and obesity in the United States, 1999–2004,” Journal of the American Medical Association, vol. 295, no. 13, pp. 1549–1555, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. G. Wang and W. H. Dietz, “Economic burden of obesity in youths aged 6 to 17 years: 1979–1999,” Pediatrics, vol. 109, no. 5, article e81, 2002. View at Scopus
  3. W. H. Dietz and T. N. Robinson, “Overweight children and adolescents,” The New England Journal of Medicine, vol. 352, no. 20, pp. 2100–2109, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. A. Fagot-Campagna, D. J. Pettitt, M. M. Engelgau, et al., “Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective,” Journal of Pediatrics, vol. 136, no. 5, pp. 664–672, 2000. View at Scopus
  5. P. Dandona, A. Aljada, and A. Bandyopadhyay, “Inflammation: the link between insulin resistance, obesity and diabetes,” Trends in Immunology, vol. 25, no. 1, pp. 4–7, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Jung, N. Fischer, M. Fritzenwanger, and H. R. Figulla, “Anthropometric indices as predictors of the metabolic syndrome and its components in adolescents,” to appear in Pediatrics International.
  7. K. Alexandraki, C. Piperi, C. Kalofoutis, J. Singh, A. Alaveras, and A. Kalofoutis, “Inflammatory process in type 2 diabetes: the role of cytokines,” Annals of the New York Academy of Sciences, vol. 1084, pp. 89–117, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. H. Xu, G. T. Barnes, Q. Yang, et al., “Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1821–1830, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. G. Fantuzzi, “Adipose tissue, adipokines, and inflammation,” Journal of Allergy and Clinical Immunology, vol. 115, no. 5, pp. 911–920, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. C. Jung, N. Fischer, M. Fritzenwanger, J. Pernow, B. R. Brehm, and H. R. Figulla, “Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents,” Pediatric Diabetes, vol. 10, no. 5, pp. 329–335, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. C. Jung, M. Fritzenwanger, N. Fischer, and H. R. Figulla, “Hepatocyte growth factor is elevated in obese adolescents,” Journal of Pediatric Endocrinology and Metabolism, vol. 22, no. 7, pp. 645–651, 2009. View at Scopus
  12. J. Y. Shin, S. Y. Kim, M. J. Jeung, et al., “Serum adiponectin, C-reactive protein and TNF-α levels in obese Korean children,” Journal of Pediatric Endocrinology and Metabolism, vol. 21, no. 1, pp. 23–29, 2008. View at Scopus
  13. C. Jung, M. Fritzenwanger, and H. R. Figulla, “Cardiotrophin-1 in adolescents: impact of obesity and blood pressure,” Hypertension, vol. 52, no. 2, article e6, 2008. View at Scopus
  14. O. Osborn, H. Gram, E. P. Zorrilla, B. Conti, and T. Bartfai, “Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance,” Swiss Medical Weekly, vol. 138, no. 45-46, pp. 665–673, 2008. View at Scopus
  15. C. E. Juge-Aubry, E. Somm, V. Giusti, et al., “Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation,” Diabetes, vol. 52, no. 5, pp. 1104–1110, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. C. A. Meier, E. Bobbioni, C. Gabay, F. Assimacopoulos-Jeannet, A. Golay, and J.-M. Dayer, “IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1184–1188, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Kromeyer-Hauschild, M. Wabitsch, D. Kunze, et al., “Perzentile für den body-mass-index für das kindes- und jugendalter unter heranziehung verschiedener deutscher stichproben,” Monatsschrift für Kinderheilkunde, vol. 149, no. 8, pp. 807–818, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. I. H. Khan, V. V. Krishnan, M. Ziman, et al., “A comparison of multiplex suspension array large-panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients,” Cytometry B, vol. 76, no. 3, pp. 159–168, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. C. Herder, S. Schneitler, W. Rathmann, et al., “Low-grade inflammation, obesity, and insulin resistance in adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 12, pp. 4569–4574, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. A. A. Meyer, G. Kundt, M. Steiner, P. Schuff-Werner, and W. Kienast, “Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors,” Pediatrics, vol. 117, no. 5, pp. 1560–1567, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante Jr., “Obesity is associated with macrophage accumulation in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796–1808, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. R. Weiss and S. Caprio, “The metabolic consequences of childhood obesity,” Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 19, no. 3, pp. 405–419, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. Perrier, F. Darakhshan, and E. Hajduch, “IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?” FEBS Letters, vol. 580, no. 27, pp. 6289–6294, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. J. S. Rosa, R. L. Flores, S. R. Oliver, A. M. Pontello, F. P. Zaldivar, and P. R. Galassetti, “Sustained IL-1α, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus,” Pediatric Diabetes, vol. 9, no. 1, pp. 9–16, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. J. He, I. Usui, K. Ishizuka, et al., “Interleukin-1α inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes,” Molecular Endocrinology, vol. 20, no. 1, pp. 114–124, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. K. Maedler, P. Sergeev, F. Ris, et al., “Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets,” Journal of Clinical Investigation, vol. 110, no. 6, pp. 851–860, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. O. Osborn, S. E. Brownell, M. Sanchez-Alavez, D. Salomon, H. Gram, and T. Bartfai, “Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity,” Cytokine, vol. 44, no. 1, pp. 141–148, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. G. J. Brunn, S. Saadi, and J. L. Platt, “Differential regulation of endothelial cell activation by complement and interleukin 1α,” Circulation Research, vol. 98, no. 6, pp. 793–800, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. D. Boraschi and A. Tagliabue, “The interleukin-1 receptor family,” Vitamins and Hormones, vol. 74, pp. 229–254, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. Z. Mallat, A. Corbaz, A. Scoazec, et al., “Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability,” Circulation, vol. 104, no. 14, pp. 1598–1603, 2001. View at Scopus
  31. A. Zirlik, S. M. Abdullah, N. Gerdes, et al., “Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 9, pp. 2043–2049, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schönbeck, “Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis,” Journal of Experimental Medicine, vol. 195, no. 2, pp. 245–257, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. E. P. Zorrilla, M. Sanchez-Alavez, S. Sugama, et al., “Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 26, pp. 11097–11102, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. K. Esposito, A. Pontillo, M. Ciotola, et al., “Weight loss reduces interleukin-18 levels in obese women,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 8, pp. 3864–3866, 2002. View at Publisher · View at Google Scholar
  35. T. Skurk, H. Kolb, S. Müller-Scholze, K. Röhrig, H. Hauner, and C. Herder, “The proatherogenic cytokine interleukin-18 is secreted by human adipocytes,” European Journal of Endocrinology, vol. 152, no. 6, pp. 863–868, 2005. View at Publisher · View at Google Scholar · View at PubMed
  36. J. N. Fain, D. S. Tichansky, and A. K. Madan, “Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes,” Metabolism: Clinical and Experimental, vol. 55, no. 8, pp. 1113–1121, 2006. View at Publisher · View at Google Scholar · View at PubMed
  37. M. G. Netea, L. A. B. Joosten, E. Lewis, et al., “Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance,” Nature Medicine, vol. 12, no. 6, pp. 650–656, 2006. View at Publisher · View at Google Scholar · View at PubMed
  38. J. Hung, B. M. McQuillan, P. L. Thompson, and J. P. Beilby, “Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity,” International Journal of Obesity, vol. 32, no. 5, pp. 772–779, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. L. Gilardini, P. G. McTernan, A. Girola, et al., “Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents,” Atherosclerosis, vol. 189, no. 2, pp. 401–407, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. G. R. C. Zilverschoon, C. J. Tack, L. A. B. Joosten, B. J. Kullberg, J. W. M. van der Meer, and M. G. Netea, “Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus,” International Journal of Obesity, vol. 32, no. 9, pp. 1407–1414, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. E. Erdem, B. A. Kogan, and P. J. Feustel, “Relationship between body mass index and pediatric urologic diagnoses,” Journal of Pediatric Urology, vol. 3, no. 4, pp. 268–272, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus