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Mediators of Inflammation
Volume 2010 (2010), Article ID 986596, 10 pages
http://dx.doi.org/10.1155/2010/986596
Review Article

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9

Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA

Received 30 November 2009; Accepted 9 March 2010

Academic Editor: Philipp M. Lepper

Copyright © 2010 Petar S. Lenert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [30 citations]

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  • Lisa A. Sorbera, Sundaravinayagam, Dulsat, and Rosa, “Therapeutic targets for systemic lupus erythematosus,” Drugs of the Future, vol. 35, no. 9, pp. 765–772, 2010. View at Publisher · View at Google Scholar
  • L. A. Sorbera, D. Sundaravinayagam, C. Dulsat, and E. Rosa, “Therapeutic Targets For Systemic Lupus Erythematosus,” Drugs of The Future, vol. 35, no. 9, pp. 765–772, 2010. View at Publisher · View at Google Scholar
  • Yoshinobu Takakura, Hiroyuki Yoshida, Makiya Nishikawa, Tsuyoshi Kiyota, Shota Uno, Hiroyasu Toyota, Rei Takahashi, and Miwako Narita, “5′-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages,” European Journal of Immunology, vol. 41, no. 2, pp. 425–436, 2010. View at Publisher · View at Google Scholar
  • Maria Eugenia Guicciardi, and Gregory J. Gores, “Apoptosis as a Mechanism for Liver Disease Progression,” Seminars in Liver Disease, vol. 30, no. 4, pp. 402–410, 2010. View at Publisher · View at Google Scholar
  • Ana M. Avalos, and Hidde L. Ploegh, “Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9,” European Journal of Immunology, vol. 41, no. 10, pp. 2820–2827, 2011. View at Publisher · View at Google Scholar
  • H. Yanai, S. Chiba, T. Ban, Y. Nakaima, T. Onoe, K. Honda, H. Ohdan, and T. Taniguchi, “Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs),” Proceedings of the National Academy of Sciences, vol. 108, no. 28, pp. 11542–11547, 2011. View at Publisher · View at Google Scholar
  • Toshiro Sada, Masao Ota, Yoshihiko Katsuyama, Akira Meguro, Eiichi Nomura, Riyo Uemoto, Tadayuki Nishide, Eiichi Okada, Shigeaki Ohno, Hidetoshi Inoko, and Nobuhisa Mizuki, “Association analysis of Toll-like receptor 7 gene polymorphisms and Behçet's disease in Japanese patients,” Human Immunology, vol. 72, no. 3, pp. 269–272, 2011. View at Publisher · View at Google Scholar
  • Hans Ulrich Scherer, and Gerd-Rüdiger Burmester, “Adaptive immunity in rheumatic diseases – Bystander or pathogenic player?,” Best Practice & Research Clinical Rheumatology, vol. 25, no. 6, pp. 785–800, 2011. View at Publisher · View at Google Scholar
  • Maciej Lech, Claudia Kantner, Onkar P. Kulkarni, Mi Ryu, Ekaterina Vlasova, Juergen Heesemann, David Anz, Stefan Endres, Koichi S. Kobayashi, Richard A. Flavell, Javier Martin, and Hans-Joachim Anders, “Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus,” Annals Of The Rheumatic Diseases, vol. 70, no. 12, pp. 2207–2217, 2011. View at Publisher · View at Google Scholar
  • S-Y Chen, A-L Shiau, Y-T Li, Y-S Lin, C-H Lee, C-L Wu, and C-R Wang, “Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene,” Gene Therapy, vol. 19, no. 7, pp. 752–760, 2011. View at Publisher · View at Google Scholar
  • T. Layer, A. Steele, J. A. Goeken, S. Fleenor, and P. Lenert, “Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice,” Clinical & Experimental Immunology, vol. 163, no. 3, pp. 392–403, 2011. View at Publisher · View at Google Scholar
  • Yong-Sheng Zhang, Xiu-Li Wu, Ying Wang, Ran Sun, Yong-Li Yu, and Li-Ying Wang, “Structure–activity relationship of a guanine-free oligodeoxynucleotide as immunopotent inhibitor,” International Immunopharmacology, vol. 13, no. 4, pp. 446–453, 2012. View at Publisher · View at Google Scholar
  • Arun Shrivastava, and Dhanita Khanna, “Antimalarials: Reversing the autoimmune "mal-area"?,” Indian Journal of Rheumatology, vol. 7, no. 2, pp. 97–101, 2012. View at Publisher · View at Google Scholar
  • Zheng Liu, and Anne Davidson, “Taming lupus—a new understanding of pathogenesis is leading to clinical advances,” Nature Medicine, vol. 18, no. 6, pp. 871–882, 2012. View at Publisher · View at Google Scholar
  • Min Chen, Marcelo de Carvalho Bittencourt, Pierre Feugier, Gilbert C. Faure, and Marie C. Béné, “Active Toll-like receptor-7 triggering of chronic lymphocytic leukemia B-cells by imiquimod,” Leukemia & Lymphoma, vol. 53, no. 4, pp. 739–742, 2012. View at Publisher · View at Google Scholar
  • Zhijun Wang, Xiuli Wu, Yongsheng Zhang, Lei Zhou, Lina Li, Yongli Yu, and Liying Wang, “Discrepant roles of CpG ODN on acute alcohol-induced liver injury in mice,” International Immunopharmacology, vol. 12, no. 3, pp. 526–533, 2012. View at Publisher · View at Google Scholar
  • Damir Matesic, Aleksander Lenert, and Petar Lenert, “Modulating Toll-like Receptor 7 and 9 Responses as Therapy for Allergy and Autoimmunity,” Current Allergy And Asthma Reports, vol. 12, no. 1, pp. 8–17, 2012. View at Publisher · View at Google Scholar
  • John S.A. Mattick, Qian Yang, Mehmet A. Orman, Marianthi G. Ierapetritou, Francois Berthiaume, and Ioannis P. Androulakis, “Long-term gene expression profile dynamics following cecal ligation and puncture in the rat,” Journal of Surgical Research, vol. 178, no. 1, pp. 431–442, 2012. View at Publisher · View at Google Scholar
  • Fui G. Goh, and Kim S. Midwood, “Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis,” Rheumatology, vol. 51, no. 1, pp. 7–23, 2012. View at Publisher · View at Google Scholar
  • Vincenzo Ciriello, Suribabu Gudipati, Petros Z Stavrou, Nikolaos K. Kanakaris, Mark C. Bellamy, and Peter V. Giannoudis, “Biomarkers predicting sepsis in polytrauma patients: Current Evidence,” Injury, 2013. View at Publisher · View at Google Scholar
  • Fu-Gang Zhu, Weiwen Jiang, Lakshmi Bhagat, Daqing Wang, Dong Yu, Jimmy X. Tang, Ekambar R. Kandimalla, Nicola La Monica, and Sudhir Agrawal, “A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice,” Autoimmunity, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Ekambar R. Kandimalla, Lakshmi Bhagat, Daqing Wang, Dong Yu, Tim Sullivan, Nicola La Monica, and Sudhir Agrawal, “Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9,” Nucleic Acids Research, vol. 41, no. 6, pp. 3947–3961, 2013. View at Publisher · View at Google Scholar
  • L. Heller, V. Todorovic, and M. Cemazar, “Electrotransfer of single-stranded or double-stranded DNA induces complete regression of palpable B16.F10 mouse melanomas,” Cancer Gene Therapy, vol. 20, no. 12, pp. 695–700, 2013. View at Publisher · View at Google Scholar
  • Eugen Uhlmann, Joerg Vollmer, Thomas Miethke, Monika Hammel, Anna Waldhuber, Lavinia Pfeiffer, Hermann Wagner, Franziska Roemmler, and Marion Jurk, “Guanine Modification of Inhibitory Oligonucleotides Potentiates Their Suppressive Function,” Journal Of Immunology, vol. 191, no. 6, pp. 3240–3253, 2013. View at Publisher · View at Google Scholar
  • O. Boehm, P. Markowski, M. van der Giet, V. Gielen, A. Kokalova, C. Brill, A. Hoeft, G. Baumgarten, R. Meyer, and P. Knuefermann, “In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction,” Mediators of Inflammation, vol. 2013, pp. 1–9, 2013. View at Publisher · View at Google Scholar
  • Yi Hao, Jian-Ling Yuan, Abulizi Abudula, Axiangu Hasimu, Nafeisha Kadeer, and Xia Guo, “TLR9 Expression in Uterine Cervical Lesions of Uyghur Women Correlate with Cervical Cancer Progression and Selective Silencing of Human Papillomavirus 16 E6 and E7 Oncoproteins in Vitro,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 14, pp. 5867–5872, 2014. View at Publisher · View at Google Scholar
  • Albert J. Czaja, “Targeting Apoptosis in Autoimmune Hepatitis,” Digestive Diseases and Sciences, 2014. View at Publisher · View at Google Scholar
  • Ulrich Jarry, Sabrina Donnou, Marie Vincent, Pascale Jeannin, Laurent Pineau, Isabelle Fremaux, Yves Delneste, and Dominique Couez, “Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection,” Journal of Neuroimmunology, vol. 267, no. 1-2, pp. 35–42, 2014. View at Publisher · View at Google Scholar
  • Margarita Dominguez-Villar, Anne-Sophie Gautron, Marine de Marcken, Marla J Keller, and David A Hafler, “TLR7 induces anergy in human CD4+ T cells,” Nature Immunology, 2014. View at Publisher · View at Google Scholar
  • Wei Jiang, and Gary Gilkeson, “Sex differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE),” Journal of Immunotherapy Applications, vol. 1, no. 1, pp. 1, 2014. View at Publisher · View at Google Scholar