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Mediators of Inflammation
Volume 2010 (2010), Article ID 986596, 10 pages
Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9
Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa 52242, USA
Received 30 November 2009; Accepted 9 March 2010
Academic Editor: Philipp M. Lepper
Copyright © 2010 Petar S. Lenert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [36 citations]
The following is the list of published articles that have cited the current article.
- Lisa A. Sorbera, Sundaravinayagam, Dulsat, and Rosa, “Therapeutic targets for systemic lupus erythematosus,” Drugs of the Future, vol. 35, no. 9, pp. 765–772, 2010.
- L. A. Sorbera, D. Sundaravinayagam, C. Dulsat, and E. Rosa, “Therapeutic Targets For Systemic Lupus Erythematosus,” Drugs of The Future, vol. 35, no. 9, pp. 765–772, 2010.
- Yoshinobu Takakura, Hiroyuki Yoshida, Makiya Nishikawa, Tsuyoshi Kiyota, Shota Uno, Hiroyasu Toyota, Rei Takahashi, and Miwako Narita, “5′-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages,” European Journal of Immunology, vol. 41, no. 2, pp. 425–436, 2010.
- Maria Eugenia Guicciardi, and Gregory J. Gores, “Apoptosis as a Mechanism for Liver Disease Progression,” Seminars in Liver Disease, vol. 30, no. 4, pp. 402–410, 2010.
- Ana M. Avalos, and Hidde L. Ploegh, “Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9,” European Journal of Immunology, vol. 41, no. 10, pp. 2820–2827, 2011.
- H. Yanai, S. Chiba, T. Ban, Y. Nakaima, T. Onoe, K. Honda, H. Ohdan, and T. Taniguchi, “Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs),” Proceedings of the National Academy of Sciences, vol. 108, no. 28, pp. 11542–11547, 2011.
- Toshiro Sada, Masao Ota, Yoshihiko Katsuyama, Akira Meguro, Eiichi Nomura, Riyo Uemoto, Tadayuki Nishide, Eiichi Okada, Shigeaki Ohno, Hidetoshi Inoko, and Nobuhisa Mizuki, “Association analysis of Toll-like receptor 7 gene polymorphisms and Behçet's disease in Japanese patients,” Human Immunology, vol. 72, no. 3, pp. 269–272, 2011.
- Hans Ulrich Scherer, and Gerd-Rüdiger Burmester, “Adaptive immunity in rheumatic diseases – Bystander or pathogenic player?,” Best Practice & Research Clinical Rheumatology, vol. 25, no. 6, pp. 785–800, 2011.
- Maciej Lech, Claudia Kantner, Onkar P. Kulkarni, Mi Ryu, Ekaterina Vlasova, Juergen Heesemann, David Anz, Stefan Endres, Koichi S. Kobayashi, Richard A. Flavell, Javier Martin, and Hans-Joachim Anders, “Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus,” Annals Of The Rheumatic Diseases, vol. 70, no. 12, pp. 2207–2217, 2011.
- S-Y Chen, A-L Shiau, Y-T Li, Y-S Lin, C-H Lee, C-L Wu, and C-R Wang, “Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene,” Gene Therapy, vol. 19, no. 7, pp. 752–760, 2011.
- T. Layer, A. Steele, J. A. Goeken, S. Fleenor, and P. Lenert, “Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice,” Clinical & Experimental Immunology, vol. 163, no. 3, pp. 392–403, 2011.
- Yong-Sheng Zhang, Xiu-Li Wu, Ying Wang, Ran Sun, Yong-Li Yu, and Li-Ying Wang, “Structure–activity relationship of a guanine-free oligodeoxynucleotide as immunopotent inhibitor,” International Immunopharmacology, vol. 13, no. 4, pp. 446–453, 2012.
- Arun Shrivastava, and Dhanita Khanna, “Antimalarials: Reversing the autoimmune "mal-area"?,” Indian Journal of Rheumatology, vol. 7, no. 2, pp. 97–101, 2012.
- Zheng Liu, and Anne Davidson, “Taming lupus—a new understanding of pathogenesis is leading to clinical advances,” Nature Medicine, vol. 18, no. 6, pp. 871–882, 2012.
- Min Chen, Marcelo de Carvalho Bittencourt, Pierre Feugier, Gilbert C. Faure, and Marie C. Béné, “Active Toll-like receptor-7 triggering of chronic lymphocytic leukemia B-cells by imiquimod,” Leukemia & Lymphoma, vol. 53, no. 4, pp. 739–742, 2012.
- Zhijun Wang, Xiuli Wu, Yongsheng Zhang, Lei Zhou, Lina Li, Yongli Yu, and Liying Wang, “Discrepant roles of CpG ODN on acute alcohol-induced liver injury in mice,” International Immunopharmacology, vol. 12, no. 3, pp. 526–533, 2012.
- Damir Matesic, Aleksander Lenert, and Petar Lenert, “Modulating Toll-like Receptor 7 and 9 Responses as Therapy for Allergy and Autoimmunity,” Current Allergy And Asthma Reports, vol. 12, no. 1, pp. 8–17, 2012.
- John S.A. Mattick, Qian Yang, Mehmet A. Orman, Marianthi G. Ierapetritou, Francois Berthiaume, and Ioannis P. Androulakis, “Long-term gene expression profile dynamics following cecal ligation and puncture in the rat,” Journal of Surgical Research, vol. 178, no. 1, pp. 431–442, 2012.
- Fui G. Goh, and Kim S. Midwood, “Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis,” Rheumatology, vol. 51, no. 1, pp. 7–23, 2012.
- Vincenzo Ciriello, Suribabu Gudipati, Petros Z Stavrou, Nikolaos K. Kanakaris, Mark C. Bellamy, and Peter V. Giannoudis, “Biomarkers predicting sepsis in polytrauma patients: Current Evidence,” Injury, 2013.
- Fu-Gang Zhu, Weiwen Jiang, Lakshmi Bhagat, Daqing Wang, Dong Yu, Jimmy X. Tang, Ekambar R. Kandimalla, Nicola La Monica, and Sudhir Agrawal, “A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice,” Autoimmunity, pp. 1–10, 2013.
- Ekambar R. Kandimalla, Lakshmi Bhagat, Daqing Wang, Dong Yu, Tim Sullivan, Nicola La Monica, and Sudhir Agrawal, “Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9,” Nucleic Acids Research, vol. 41, no. 6, pp. 3947–3961, 2013.
- L. Heller, V. Todorovic, and M. Cemazar, “Electrotransfer of single-stranded or double-stranded DNA induces complete regression of palpable B16.F10 mouse melanomas,” Cancer Gene Therapy, vol. 20, no. 12, pp. 695–700, 2013.
- O. Boehm, P. Markowski, M. van der Giet, V. Gielen, A. Kokalova, C. Brill, A. Hoeft, G. Baumgarten, R. Meyer, and P. Knuefermann, “In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction,” Mediators of Inflammation, vol. 2013, pp. 1–9, 2013.
- Eugen Uhlmann, Joerg Vollmer, Thomas Miethke, Monika Hammel, Anna Waldhuber, Lavinia Pfeiffer, Hermann Wagner, Franziska Roemmler, and Marion Jurk, “Guanine Modification of Inhibitory Oligonucleotides Potentiates Their Suppressive Function,” Journal Of Immunology, vol. 191, no. 6, pp. 3240–3253, 2013.
- Yi Hao, Jian-Ling Yuan, Abulizi Abudula, Axiangu Hasimu, Nafeisha Kadeer, and Xia Guo, “TLR9 Expression in Uterine Cervical Lesions of Uyghur Women Correlate with Cervical Cancer Progression and Selective Silencing of Human Papillomavirus 16 E6 and E7 Oncoproteins in Vitro,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 14, pp. 5867–5872, 2014.
- Albert J. Czaja, “Targeting Apoptosis in Autoimmune Hepatitis,” Digestive Diseases and Sciences, 2014.
- Ulrich Jarry, Sabrina Donnou, Marie Vincent, Pascale Jeannin, Laurent Pineau, Isabelle Fremaux, Yves Delneste, and Dominique Couez, “Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection,” Journal of Neuroimmunology, vol. 267, no. 1-2, pp. 35–42, 2014.
- Wei Jiang, Lumin Zhang, Ren Lang, Zihai Li, and Gary Gilkeson, “Sex Differences in Monocyte Activation in Systemic Lupus Erythematosus (SLE),” Plos One, vol. 9, no. 12, 2014.
- Margarita Dominguez-Villar, Anne-Sophie Gautron, Marine de Marcken, Marla J Keller, and David A Hafler, “TLR7 induces anergy in human CD4+ T cells,” Nature Immunology, 2014.
- Wei Jiang, and Gary Gilkeson, “Sex differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE),” Journal of Immunotherapy Applications, vol. 1, no. 1, pp. 1, 2014.
- Franziska Roemmler, Monika Hammel, Anna Waldhuber, Tina Mueller, Marion Jurk, Eugen Uhlmann, Hermann Wagner, Joerg Vollmer, and Thomas Miethke, “Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7-and TLR9-Mediated Immune Responses of Human Immune Cells,” Plos One, vol. 10, no. 2, 2015.
- Umeharu Ohto, Takuma Shibata, Hiromi Tanji, Hanako Ishida, Elena Krayukhina, Susumu Uchiyama, Kensuke Miyake, and Toshiyuki Shimizu, “Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9,” Nature, 2015.
- Zhuo Wang, Zhong Deng, Nadia Dahmane, Kevin Tsai, Pu Wang, Dewight R. Williams, Andrew V. Kossenkov, Louise C. Showe, Rugang Zhang, Qihong Huang, Jose R. Conejo-Garcia, and Paul M. Lieberman, “Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes,” Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 112, no. 46, pp. E6293–E6300, 2015.
- Mark Phillippe, “Cell-Free Fetal DNA, Telomeres, and the Spontaneous Onset of Parturition,” Reproductive Sciences, vol. 22, no. 10, pp. 1186–1201, 2015.
- Masakatsu Takanashi, Katsuko Sudo, Shinobu Ueda, Shin-Ichiro Ohno, Yuko Yamada, Yasuhiro Osakabe, Hiroshi Goto, Yoshimichi Matsunaga, Akio Ishikawa, Yoshihiko Usui, and Masahiko Kuroda, “Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model,” Molecular Therapy—Nucleic Acids, vol. 4, no. 10, pp. e258, 2015.