Review Article
Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9
Table 2
Classification of inhibitory oligonucleotides.
| Class | Characteristics | Prototype | TLR9 inhibition in B cells | TLR9 inhibition in DC/MΦ | TLR7 inhibition (backbone effect) | Inhibition of other signaling pathways | Reference |
| G | G4-stacking | TTAGGGn | + | +++ | ++ | +++ | [61] | R | Palindromic, Short 5 or 3overhangs | INH-1 | + | +++ | ++ | — | [62] | B | Linear | INH-18 | +++ | +++ | ++ | — | [62] |
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