Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9

Table 2

Classification of inhibitory oligonucleotides.

Class	Characteristics	Prototype	TLR9 inhibition in B cells	TLR9 inhibition in DC/MΦ	TLR7 inhibition (backbone effect)	Inhibition of other signaling pathways	Reference
G	G4-stacking	TTAGGGn	+	+++	++	+++	[61]
R	Palindromic, Short 5${}^{\prime }$ or 3${}^{\prime }$overhangs	INH-1	+	+++	++	—	[62]
B	Linear	INH-18	+++	+++	++	—	[62]