Research Article
Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury
Table 1
Experimental design of the preliminary research.
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In acute necrotizing pancreatitis group, rats received the vehicle (10% DMSO, 2 mL/kg) administered via femoral vein half an hour prior to retrograde infusion of a freshly prepared 5% sodium taurocholate solution (1 mg/kg). In sham-operated group, rats received the vehicle administered via femoral vein and after half an hour, the rats were retrograde infused isotonic saline solution (1 mL/kg). In zerumbone pretreated group, rats received 5, 10, 20, and 40 mg/kg zerumbone dissolved in vehicle (10% DMSO v/v) administered via femoral vein half an hour prior to infusion 5% sodium taurocholate solution (1 mg/kg). |