Effects of Trauma-Hemorrhage and IL-6 Deficiency on Splenic Immune Function in a Murine Trauma Model

<table>IL-6 productive capacity of splenocytes in response to their stimulation with LPS in wild-type (WT) and IL-6 knockout (IL-6<sup>−/−</sup>) mice in sham animals (group S), after an isolated femoral fracture (group Fx) and after the combination of a femoral fracture and hemorrhage (group TH-Fx). *stat. significance (<svg height="11.375" id="M15" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 70.050003 11.375" width="70.050003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.26,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,41.624,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.784,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.66,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.819,11.112)"><use xlink:href="#x35"></use></g>
</svg>) S vs. Fx and TH-Fx, <sup>#</sup>stat. significance (<svg height="11.375" id="M16" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x35"></use></g>
</svg>) Fx versus. TH-Fx, <sup>$</sup>stat. significance (<svg height="11.375" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 70.050003 11.375" width="70.050003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.26,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,41.624,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.784,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.66,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.819,11.112)"><use xlink:href="#x35"></use></g>
</svg>) WT versus. IL-6<sup>−/−</sup>.</table>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Effects of Trauma-Hemorrhage and IL-6 Deficiency on Splenic Immune Function in a Murine Trauma Model 