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Mediators of Inflammation
Volume 2012 (2012), Article ID 207398, 12 pages
The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells
Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, Calgary, AB, T2N 1N4, Canada
Received 7 January 2012; Accepted 24 July 2012
Academic Editor: Thirumala-Devi Kanneganti
Copyright © 2012 Humberto B. Jijon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. B. Sartor and M. Muehlbauer, “Microbial host interactions in IBD: implications for pathogenesis and therapy,” Current Gastroenterology Reports, vol. 9, no. 6, pp. 497–507, 2007.
- E. Burstein and E. R. Fearon, “Colitis and cancer: a tale of inflammatory cells and their cytokines,” The Journal of Clinical Investigation, vol. 118, no. 2, pp. 464–467, 2008.
- J. A. P. Wilson, “Tumor necrosis factor α and colitis-associated colon cancer,” The New England Journal of Medicine, vol. 358, no. 25, pp. 2733–2734, 2008.
- F. Balkwill and L. M. Coussens, “Cancer: an inflammatory link,” Nature, vol. 431, no. 7007, pp. 405–406, 2004.
- R. C. Bates, M. J. Deleo, and A. M. Mercurio, “The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis,” Experimental Cell Research, vol. 299, no. 2, pp. 315–324, 2004.
- A. Sparmann and D. Bar-Sagi, “Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis,” Cancer Cell, vol. 6, no. 5, pp. 447–458, 2004.
- J. Wang and Y. X. Fu, “Tumor necrosis factor family members and inflammatory bowel disease,” Immunological Reviews, vol. 204, pp. 144–155, 2005.
- C. P. Braegger, S. Nicholls, S. H. Murch, S. Stephens, and T. T. MacDonald, “Tumour necrosis factor alpha in stool as a marker of intestinal inflammation,” The Lancet, vol. 339, no. 8785, pp. 89–91, 1992.
- M. Komatsu, D. Kobayashi, K. Saito et al., “Tumor necrosis factor-α in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR,” Clinical Chemistry, vol. 47, no. 7, pp. 1297–1301, 2001.
- S. B. Hanauer, B. G. Feagan, G. R. Lichtenstein et al., “Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial,” The Lancet, vol. 359, no. 9317, pp. 1541–1549, 2002.
- G. Järnerot, E. Hertervig, I. Friis-Liby et al., “Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study,” Gastroenterology, vol. 128, no. 7, pp. 1805–1811, 2005.
- S. R. Targan, S. B. Hanauer, S. J. H. Van Deventer et al., “A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's Disease,” The New England Journal of Medicine, vol. 337, no. 15, pp. 1029–35, 1997.
- B. K. Popivanova, K. Kitamura, Y. Wu et al., “Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis,” The Journal of Clinical Investigation, vol. 118, no. 2, pp. 560–570, 2008.
- S. Dionne, I. D. D'Agata, F. M. Ruemmele et al., “Tyrosine kinase and MAPK inhibition of TNF-α- and EGF-stimulated IEC-6 cell growth,” Biochemical and Biophysical Research Communications, vol. 242, no. 1, pp. 146–150, 1998.
- G. C. Kaiser and D. B. Polk, “Tumor necrosis factor α regulates proliferation in a mouse intestinal cell line,” Gastroenterology, vol. 112, no. 4, pp. 1231–1240, 1997.
- G. C. Kaiser, F. Yan, and D. B. Polk, “Conversion of TNFα from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase,” Experimental Cell Research, vol. 249, no. 2, pp. 349–358, 1999.
- C. W. Marano, S. A. Lewis, L. A. Garulacan, A. Peralta Soler, and J. M. Mullin, “Tumor necrosis factor-α increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line,” Journal of Membrane Biology, vol. 161, no. 3, pp. 263–274, 1998.
- M. Mehran, E. Seidman, R. Marchand, C. Gurbindo, and E. Levy, “Tumor necrosis factor-α inhibits lipid and lipoprotein transport by Caco-2 cells,” American Journal of Physiology, vol. 269, no. 6, pp. G953–G960, 1995.
- T. Hehlgans and D. N. Männel, “The TNF-TNF receptor system,” Biological Chemistry, vol. 383, no. 10, pp. 1581–1585, 2002.
- T. Hehlgans and K. Pfeffer, “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games,” Immunology, vol. 115, no. 1, pp. 1–20, 2005.
- T. A. Bird and J. Saklatvala, “IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism,” Journal of Immunology, vol. 142, no. 1, pp. 126–133, 1989.
- A. Wells, “EGF receptor,” International Journal of Biochemistry and Cell Biology, vol. 31, no. 6, pp. 637–643, 1999.
- C. J. Marshall, “Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation,” Cell, vol. 80, no. 2, pp. 179–185, 1995.
- R. A. Heller and M. Krönke, “Tumor necrosis factor receptor-mediated signaling pathways,” Journal of Cell Biology, vol. 126, no. 1, pp. 5–9, 1994.
- E. Hildt and S. Oess, “Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I,” Journal of Experimental Medicine, vol. 189, no. 11, pp. 1707–1714, 1999.
- T. A. Navas, D. T. Baldwin, and T. A. Stewart, “RIP2 is a Raf1-activated mitogen-activated protein kinase kinase,” The Journal of Biological Chemistry, vol. 274, no. 47, pp. 33684–33690, 1999.
- A. R. Schievella, J. H. Chen, J. R. Graham, and L. L. Lin, “MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase,” The Journal of Biological Chemistry, vol. 272, no. 18, pp. 12069–12075, 1997.
- F. Yan, S. K. John, and D. B. Polk, “Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor,” Cancer Research, vol. 61, no. 24, pp. 8668–8675, 2001.
- F. Yan, S. K. John, G. Wilson, D. S. Jones, M. K. Washington, and D. B. Polk, “Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation,” The Journal of Clinical Investigation, vol. 114, no. 9, pp. 1272–1280, 2004.
- G. M. Argast, J. S. Campbell, J. T. Brooling, and N. Fausto, “Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication,” The Journal of Biological Chemistry, vol. 279, no. 33, pp. 34530–34536, 2004.
- W. N. U. Chen, R. L. Woodbury, L. E. Kathmann et al., “Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha,” The Journal of Biological Chemistry, vol. 279, no. 18, pp. 18488–18496, 2004.
- H. B. Jijon, W. J. Panenka, K. L. Madsen, and H. G. Parsons, “MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism,” American Journal of Physiology, vol. 283, no. 1, pp. C31–C41, 2002.
- Y. Mizukami, W. S. Jo, E. M. Duerr et al., “Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells,” Nature Medicine, vol. 11, no. 9, pp. 992–997, 2005.
- N. J. Donato, G. E. Gallick, P. A. Steck, and M. G. Rosenblum, “Tumor necrosis factor modulates epidermal growth factor receptor phosphorylation and kinase activity in human tumor cells. Correlation with cytotoxicity,” The Journal of Biological Chemistry, vol. 264, no. 34, pp. 20474–20481, 1989.
- L. Guazzoni, P. Perego, P. Banfi, and F. Zunino, “Modulation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor,” Cancer Letters, vol. 57, no. 2, pp. 103–108, 1991.
- H. Izumi, M. Ono, S. Ushiro, K. Kohno, H. Kung, and M. Kuwano, “Cross talk of tumor necrosis factor-α and epidermal growth factor in human microvascular endothelial cells,” Experimental Cell Research, vol. 214, no. 2, pp. 654–662, 1994.
- S. Murthy, S. N. Mathur, and F. J. Field, “Tumor necrosis factor-α and interleukin-1β inhibit apolipoprotein B secretion in CaCo-2 cells via the epidermal growth factor receptor signaling pathway,” The Journal of Biological Chemistry, vol. 275, no. 13, pp. 9222–9229, 2000.
- L. M. Varela, K. M. Darcy, and M. M. Ip, “The epidermal growth factor receptor is not required for tumor necrosis factor-α action in normal mammary epithelial cells,” Endocrinology, vol. 138, no. 9, pp. 3891–3900, 1997.
- D. F. McCole, S. J. Keely, R. J. Coffey, and K. E. Barrett, “Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-α,” The Journal of Biological Chemistry, vol. 277, no. 45, pp. 42603–42612, 2002.
- N. Prenzel, O. M. Fischer, S. Streit, S. Hart, and A. Ullrich, “The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification,” Endocrine-Related Cancer, vol. 8, no. 1, pp. 11–31, 2001.
- N. Prenzel, E. Zwick, M. Leserer, and A. Ullrich, “Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor: convergence point for signal integration and diversification,” Breast Cancer Research, vol. 2, no. 3, pp. 184–190, 2000.
- P. A. Kenny, “TACE: a new target in epidermal growth factor receptor dependent tumors,” Differentiation, vol. 75, no. 9, pp. 800–808, 2007.
- T. Kirkegaard, G. Pedersen, T. Saermark, and J. Brynskov, “Tumour necrosis factor-α converting enzyme (TACE) activity in human colonic epithelial cells,” Clinical and Experimental Immunology, vol. 135, no. 1, pp. 146–153, 2004.
- K. A. Janes, S. Gaudet, J. G. Albeck, U. B. Nielsen, D. A. Lauffenburger, and P. K. Sorger, “The response of human epithelial cells to TNF involves an inducible autocrine cascade,” Cell, vol. 124, no. 6, pp. 1225–1239, 2006.
- S. J. Keely, S. O. Calandrella, and K. E. Barrett, “Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells is mediated by intracellular Ca2+, PYK-2, and p60src,” The Journal of Biological Chemistry, vol. 275, no. 17, pp. 12619–12625, 2000.
- Y. Yarden and M. X. Sliwkowski, “Untangling the ErbB signalling network,” Nature Reviews Molecular Cell Biology, vol. 2, no. 2, pp. 127–137, 2001.
- Y. Zhou and M. G. Brattain, “Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis,” Cancer Research, vol. 65, no. 13, pp. 5848–5856, 2005.
- C. Jobin, L. Holt, C. A. Bradham, K. Streetz, D. A. Brenner, and R. B. Sartor, “TNF receptor-associated factor-2 is involved in both IL-1β and TNF-α signaling cascades leading to NF-κb activation and IL-8 expression in human intestinal epithelial cells,” Journal of Immunology, vol. 162, no. 8, pp. 4447–4454, 1999.
- C. Jobin and R. Balfour Sartor, “The IκB/NF-κB system: a key determinant of mucosal inflammation and protection,” American Journal of Physiology, vol. 278, no. 3, pp. C451–C462, 2000.
- G. Sethi, K. S. Ahn, M. M. Chaturvedi, and B. B. Aggarwal, “Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα,” Oncogene, vol. 26, no. 52, pp. 7324–7332, 2007.
- G. M. Myhre, M. Toruner, S. Abraham, and L. J. Egan, “Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution,” American Journal of Physiology, vol. 287, no. 6, pp. G1213–G1219, 2004.
- T. Yamaoka, F. Yan, H. Cao et al., “Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 33, pp. 11772–11777, 2008.
- S. Danese, M. Sans, C. de la Motte et al., “Angiogenesis as a novel component of inflammatory bowel disease pathogenesis,” Gastroenterology, vol. 130, no. 7, pp. 2060–2073, 2006.
- B. Khor, A. Gardet, and R. J. Xavier, “Genetics and pathogenesis of inflammatory bowel disease,” Nature, vol. 474, no. 7351, pp. 307–317, 2011.
- S. Eikawa, Y. Ohue, K. Kitaoka et al., “Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6-and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6,” Journal of Immunology, vol. 185, no. 11, pp. 6734–6740, 2010.
- S. Goel, D. G. Duda, L. Xu et al., “Normalization of the vasculature for treatment of cancer and other diseases,” Physiological Reviews, vol. 91, no. 3, pp. 1071–1121, 2011.