Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand
Figure 4
Radioresistant mast cells were involved in suppression of neutrophil recruitment by Tolerimod1 treatment. (a) WT, (b) , or chimeric mice [WT→ (c), and →WT (d)] were treated with 200 nmol Tolerimod1 (TLM1) s.c. for 3 days and peritonitis was induced with TG ( to 8 per group). (e) Mast cell-deficient mice or mice reconstituted with WT mast cells were treated with 200 nmol Tolerimod1 (TLM1) s.c. for 3 days, and peritonitis was induced with i.p. TG. The peritoneal cells were recovered by lavage after 3 hours and quantitated. Data shown are mean ± SEM and are pooled from 2 independent experiments that showed similar trends. P values are from comparisons of vehicle (veh)- and Tolerimod1-treated groups by Mann-Whitney test.
