Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells
Figure 1
Effects of azithromycin (AZM, 5–10 mg/kg), clarithromycin (CAM, 5–10 mg/kg), josamycin (JM, 10 mg/kg), or ampicillin (ABPC, 30 mg/kg) on OVA-induced mucus production in OVA-sensitized rats (). Significant increase in intraepithelial mucosubstance occurred 24 hours after 3 days of OVA instillation. Oral administration of AZM or CAM significantly inhibited antigen-induced mucus production, whereas JM and ABPC had no effect.
