Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells
Figure 2
Effects of azithromycin (AZM, 10 mg/kg), clarithromycin (CAM, 10 mg/kg), josamycin (JM, 10 mg/kg), or ampicillin (ABPC, 30 mg/kg) on LPS-induced mucus production in rat nasal epithelium (). Significant increase in intraepithelial mucosubstance occurred 24 hours after 3 days of LPS instillation. Oral administration of AZM or CAM significantly inhibited LPS-induced mucus production, whereas JM and ABPC had no effect.
