Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells

<table>Effects of azithromycin (AZM), clarithromycin (CAM), josamycin (JM), and ampicillin (ABPC) on TNF-<i>α</i> (20 ng/mL)-induced MUC5AC secretion from NCI-H292 cells (<svg height="10.925" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.65)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.65)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.65)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
l-26 -65h-233z" id="x35"></path></g>
</svg>). TNF-<i>α</i> stimulated mucin secretion. AZM and CAM significantly inhibited TNF-<i>α</i>-induced MUC5AC secretion, whereas JM and ABPC had no effect.</table>

Mediators of Inflammation

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Figure 3

Figure 3: Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells 