Prostaglandin E_𝟐 and the Suppression of Phagocyte Innate Immune Responses in Different Organs

Table 1

Prostaglandin E₂ Synthesis and Receptor Expression in Leukocytes from different organs.

Type of compartment	Type of cells	Relative synthetic capacity	Receptor expression
			EP1	EP2	EP3	EP4
	Neutrophils	−	+	+^&	+	+^&
Lung	Alveolar macrophages	+++	−	+++	+	++
	Dendritic cells	+*	+	++^&	+	++^&
	Neutrophils	−	ND	ND	ND	ND
Spleen	Macrophages	+*	ND	ND	ND	ND
	Dendritic cells	+	ND	ND	ND	ND
Bone	BMDM-derived	+++	+	+++	+	+++
	osteoclasts	+	+	++	+	++

Relative synthetic capacity is expressed by the number of plus (+) signs; a minus sign (−) characterizes no or a negligible synthetic capacity. Receptor expression is classified as positive (+), negative (−), minimal (±), or not determined (ND). *Synthesis of PGE₂ is relatively low in unstimulated conditions but is upregulated upon stimulation. ^&Receptor expression is upregulated during inflammatory stimulus.