Erythromycin Enhances CD4⁺ Foxp3⁺ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation

Figure 5

Treatment with erythromycin increases the levels of IL-35 in the lungs of rats. The levels of IL-35 in BALF of individual rats were analyzed by ELISA. Data shown are mean values of individual samples from three separate experiments and mean values (lines) of each group of rats (𝑛=10). Group N: rats exposed to regular air without any special treatment; Group C: rats exposed to regular air and were treated with erythromycin; Group S: rats exposed to smoking air and were treated with saline; and Group E: rats exposed to smoking air and were treated with erythromycin daily for nine weeks beginning at the forth weeks smoking. *𝑃<0.05, **𝑃<0.01.