Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

Table 4

The risk of the acute coronary syndrome for primary variables.

Parameter	Crude odds ratio	Adjusted odds ratio
	Model 0*  OR (95% CI); P value for the model	Model 1 OR (95% CI); P value for the model	Model 2 OR (95% CI); P value for the model	Model 3 OR (95% CI); P value for the model
TC	1.08 (0.94–1.22)	1.10 (0.98–1.23)	1.12 (1.01–1.25)	1.04 (0.83–1.3)
	ns	ns	0.029	ns
LDL-C	0.94 (0.82–1.07)	0.92 (0.82–1.03)	0.9 (0.81–1.00)	0.99 (0.8–1.23)
	ns	ns	0.05	ns
HDL-C	0.89 (0.78–1.01)	0.9 (0.8–1.00)	0.88 (0.8–0.98)	0.84 (0.67–1.06)
	ns	ns	0.019	ns
TG	0.99 (0.96–1.02)	0.99 (0.97–1.02)	0.98 (0.96–1.01)	1.00 (0.96–1.05)
	ns	ns	ns	ns
apoA-I	0.99 (0.98–1.01)	0.96 (0.94–0.99)	0.97 (0.95–0.99)	0.99 (0.96–1.02)
	ns	0.002	0.005	ns
apoB	1.01 (0.99–1.03)	1.01 (0.98–1.03)	1.01 (0.98–1.04)	1.01 (0.95–1.07)
	ns	ns	ns	ns
hsCRP	1.60 (1.32–1.94)	1.55 (1.21–1.98)	1.64 (1.26–2.12)	1.66 (1.2–2.29)
	0.0001	0.0001	0.0001	0.002

*Model 0 unadjusted: 𝜒² = 131.7; df = 7; P < 0.001; log-likelihood = 275.5; 𝑅² Cox and Snell = 0.34; 𝑅² Nagelkerke = 0.47.
Model 1 adjusted for age: 𝜒² = 241.9; df = 8; P < 0.001; log-likelihood = 165.3; 𝑅² Cox and Snell = 0.53; 𝑅² Nagelkerke = 0.74.
Model 2 adjusted for age and sex: 𝜒² = 251.0; df = 9; P < 0.001; log-likelihood = 156.2; 𝑅² Cox and Snell = 0.54; 𝑅² Nagelkerke = 0.75.
Model 3 adjusted for age, sex, and smoking status: 𝜒² = 219.7; df = 10; P < 0.001; log-likelihood = 64.6; 𝑅² Cox and Snell = 0.62; 𝑅² Nagelkerke = 0.86.
apoA-I: apolipoprotein A-I; apoB: apolipoprotein B; CI: confidence interval; HDL-C: high-density lipoprotein cholesterol; hsCRP: high-sensitivity C-reactive protein; LDL-C: low-density lipoprotein cholesterol; ns: not significant; OR: odds ratio; TC: total cholesterol; TG: triglycerides.