Clinical Study

Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

Table 6

Diagnostic usefulness of the assayed parameters for the occurrence of ACS.

VariableCut-off valueSensitivitySpecificityPositive predictive valueNegative predictive value

CRP (mg/L)
0.85*0.840.6286%58%
3.00#0.480.8990%46%
TC : HDL-C3.720.770.7988%63%
LDL-C : HDL-C2.150.760.7084%59%
TG : HDL-C1.550.850.5981%66%
apoB : apoA-I0.530.740.5677%51%

*The optimal cut-off value for hsCRP test determined by ROC analysis in our study.
#A lower limit for the high risk category according the CDC and AHA statement on markers of inflammation and cardiovascular disease [6].
ACS: acute coronary syndrome; AHA: the American Heart Association; apoB : apoA-I: apolipoprotein B to apolipoprotein A-I ratio; CDC: the Centers for Disease Control and Prevention; CRP: C-reactive protein; LDL-C : HDL-C: low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio; TC : HDL-C: total cholesterol to high-density lipoprotein cholesterol ratio; TG : HDL-C: triglycerides to high-density lipoprotein cholesterol ratio.